Pharmaceutisch Weekblad

, Volume 6, Issue 2, pp 80–87 | Cite as

Isolation and identification of 4-hydroxysulfamerazine and preliminary studies on its pharmacokinetics in dogs

  • T. B. Vree
  • M. W. Tijhuis
  • J. F. M. Nouws
  • Y. A. Hekster
Original Articles


For the following compounds: sulfamerazine, 4-hydroxysulfamerazine, N4acetylsulfamerazine, N4-acetyl4-hydroxysulfamerazine, the following data are reported: biosynthesis in the dog, isolation, identification by MS and NMR, TLC (Rf values) and HPLC (capacity factors and molar extinction), half-life of elimination, metabolism, renal excretion and protein binding in dog. Dogs are unable to acetylate sulfamerazine, but eliminate predominantly by hydroxylation of the N1-substituent. Administered N4-acetylsulfamerazine is predominantly eliminated by deacetylation to sulfamerazine which in turn is hydroxylated. The renal clearances of sulfamerazine and N4-acetylsulfamerazine in the dog are identical. The renal excretion of both compounds proceeds by the passive processes of glomerular filtration and tubular reabsorption.4-Hydroxysulfamerazine and its glucuronide have a higher renal clearance than sulfamerazine.


Public Health Internal Medicine Glomerular Filtration Renal Clearance Renal Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • T. B. Vree
    • 1
  • M. W. Tijhuis
    • 1
  • J. F. M. Nouws
    • 2
  • Y. A. Hekster
    • 1
  1. 1.Department of Clinical Pharmacy and Anaesthesiology, Sint Radboud HospitalUniversity of NijmegenHB NijmegenThe Netherlands
  2. 2.Meat Inspection ServiceAA NijmegenThe Netherlands

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