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Pharmaceutisch Weekblad

, Volume 6, Issue 2, pp 75–79 | Cite as

A new and improved gas Chromatographic method for the determination of fluoride in plasma and faeces

  • J. H. Glerum
  • A. van Dijk
  • S. W. Klein
Original Articles

Abstract

A method is described that extracts fluoride selectively as trimethylfluorosilane using carbon tetrachloride and trimethylchlorosilane. Drawbacks of other methods as well as advantages of the proposed method are discussed.

The method is directly applicable to plasma and faeces samples, has a short gas Chromatographic run time due to the use of a backflush technique and is suitable for automation. Its lowest quantifiable limit for plasma and faeces is 10 μg/l and 1 μg/g fluoride respectively, using 1.0 ml or 1.0 g samples. Preliminary pharmacokinetic parameters of fluoride obtained in two subjects are reported.

Keywords

Internal Medicine Fluoride Pharmacokinetic Parameter Faeces Sample Tetrachloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • J. H. Glerum
    • 1
    • 2
  • A. van Dijk
    • 1
  • S. W. Klein
    • 1
  1. 1.Department of Hospital PharmacyState University Hospital UtrechtGV UtrechtThe Netherlands
  2. 2.Department of Biopharmaceutics, Biopharmaceutical LaboratoryState University of UtrechtGV UtrechtThe Netherlands

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