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Pharmaceutisch Weekblad

, Volume 9, Issue 5, pp 274–282 | Cite as

Native starch in tablet formulations: Properties on compaction

  • C. E. Bos
  • G. K. Bolhuis
  • H. van Doorne
  • C. F. Lerk
Original Articles

Abstract

Maize, potato, rice and tapioca (cassava) starch were evaluated with respect to their properties on direct compression. Rice starch showed much better compactibility as compared to maize, potato and tapioca starch. Moreover, its binding capacity proved to be almost insensitive to mixing with magnesium stearate. This in contrast to the dramatic decrease in crushing strength of potato starch tablets containing the lubricant. The compactibility of the starches was found to be strongly affected by the equilibrium moisture content of the starches, which is dependent on the relative humidity of the atmosphere under which the powders were stored. All starches showed adequate capacity for water uptake to act as a disintegrant. Rice starch exhibited worst flowability, caused by its fine particle size as compared to the other starches. Granulation of rice starch changed it into a potential filler-binder in tablets prepared by direct compression.

Key words

Compression Disintegration Lubrication Starch, cassava Starch, corn Starch, potato Starch, rice Tablets 

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References

  1. 1.
    Liebermann HA, Lachmann L. Pharmaceutical dosage forms: tablets. New York: Marcel Dekker Inc., 1980.Google Scholar
  2. 2.
    Juslin M, Kahela P, Paronen P, Turakka L. Comparative evaluation of starches as tablet adjuvants. Act Pharm Fenn 1981;90:83–93.Google Scholar
  3. 3.
    Bolhuis GK, Lerk CF, Zijlstra HT, De Boer AH. Film formation by magnesium stearate during mixing and its effect on tabletting. Pharm Weekbl 1975;110:317–25.Google Scholar
  4. 4.
    Klein K. Grundlagen und Anwendungen einer durch Flammenhydrolyse gewonnen Kieselsäure 4. Aerosil zur Verbesserung des Fliessverhaltens pulverformige Substanzen. Chem Tech Ind 1968;64:849–58.Google Scholar
  5. 5.
    Allen T. Particle size measurement. 2nd ed. London: Chapman and Hall, 1975:328–37.Google Scholar
  6. 6.
    Anonymous. Katalog Pharmazeutischer Hilfstoffe. Basle: Ciba-Geigy/Hoffmann-La Roche/Sandoz, 1974.Google Scholar
  7. 7.
    Van Kamp HV, Bolhuis GK, De Boer AH, Lerk CF, Lie-A-Huen L. The role of water uptake on tablet disintegration. Pharm Act Helv 1986;61:1–8.Google Scholar
  8. 8.
    Grimm W. Stability testing in industry for worldwide marketing. Drug Dev Ind Pharm 1986;12:1259–92.Google Scholar
  9. 9.
    Zografi G, Kontny MJ. The interactions of water with cellulose and starch-derived pharmaceutical excipients. Pharm Res 1986;3:187–94.CrossRefGoogle Scholar
  10. 10.
    Swinkels JJM. Starch conversion technology. New York: Marcel Dekker Inc., 1985:15.Google Scholar
  11. 11.
    Johansson ME, Nicklasson M. Influence of mixing time, particle size and colloidal silica on the surface coverage and lubrication of magnesium stearate. Proceedings of the 5th Pharmaceutical Technology Conference, Harrogate. Liverpool: Solid Dosage Research Unit, 1986:217–25.Google Scholar
  12. 12.
    Duberg M, Nyström C. Studies on direct compression of tablets VI: Evaluation of methods for the estimation of particle fragmentation during compaction. Act Pharm Suec 1982;19:421–36.Google Scholar
  13. 13.
    Bolhuis GK, Smallenbroek AJ, Lerk CF. Interaction of tablet disintegrants and magnesium stearate during mixing 1: Effect on tablet disintegration. J Pharm Sci 1981;70:1328–30.PubMedGoogle Scholar
  14. 14.
    Commons KC, Bergen A, Walker GC. Influence of starch concentration on the disintegration time of tolbutamide tablets. J Pharm Sci 1968;57:1253–4.PubMedGoogle Scholar
  15. 15.
    Khan KA, Rhodes CT. Efficiency of disintegrants in tablet formulations. Man Chem Aerosol N 1973:48–54.Google Scholar
  16. 16.
    Gillard J, François A, Hermans Y, Roland M. Influence d'agents désintégrants sur la texture de comprimés a base de monohydrogénophosphates calciques de granulométries homogènes. J Pharm Belg 1973;28:395–409.PubMedGoogle Scholar

Copyright information

© Bohn, Scheltema & Holkema 1987

Authors and Affiliations

  • C. E. Bos
    • 1
  • G. K. Bolhuis
    • 1
  • H. van Doorne
    • 1
  • C. F. Lerk
    • 1
  1. 1.Laboratory for Pharmaceutical Technology and DispensingState University of GroningenAW Groningenthe Netherlands

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