Pharmaceutisch Weekblad

, Volume 9, Issue 5, pp 265–273 | Cite as

Optimization of a formulation for direct compression using a simplex lattice design

  • Herman V. van Kamp
  • Gerad K. Bolhuis
  • Coenraad F. Lerk
Original Articles


In this paper it is demonstrated how the optimum composition of a mixture for direct compression consisting of α-lactose monohydrate, roller-dried β-lactose and microcrystalline cellulose can be found using a systematic optimization technique. The experiments were chosen according to a simplex lattice design. The results of these experiments were used to fit a mathematical model, which then can predict the properties of all possible mixture compositions and enables a graphic representation of these properties in the form of contour plots. At a level of 4% the effect of three disintegrants (sodium starch glycolate, croscarmellose sodium and crospovidone) on the properties of the tablets compressed from these filler-binders, was evaluated by superimposing the contour plots of the different tablet responses. It was found that all the disintegrants used were effective in this combination of filler-binders. In order to evaluate drug dissolution rate an extra experiment with crospovidone as the disintegrant was performed, in which oxazepam was used as a test drug.

Key words

Cellulose Compaction Crushing strength Disintegration time Friability Lactose Optimization Tablets 


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Copyright information

© Bohn, Scheltema & Holkema 1987

Authors and Affiliations

  • Herman V. van Kamp
    • 1
  • Gerad K. Bolhuis
    • 1
  • Coenraad F. Lerk
    • 1
  1. 1.Laboratory for Pharmaceutical Technology and DispensingState University of GroningenAW Groningenthe Netherlands

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