, Volume 40, Issue 4, pp 359–361 | Cite as

A rat mutant unable to synthesize vitamin C

  • Y. Mizushima
  • T. Harauchi
  • T. Yoshizaki
  • S. Makino
Short Communications


A colony of Wistar rats with a hereditary defect in L-ascorbic acid-synthesizing ability was established. This rat, like primates and guinea pigs, lacks L-gulonolactone oxidase (EC which catalyzes the last step of L-ascorbic acid biosynthesis. When L-ascorbic acid was added to their drinking water, the rats grew almost normally and were fertile. These mutant rats should be useful not only for nutritional and parmacological studies on vitamin C but also for genetic studies on the lack of this enzyme.


Enzyme Drinking Water Genetic Study Acid Biosynthesis Hereditary Defect 
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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Y. Mizushima
    • 1
    • 2
  • T. Harauchi
    • 1
    • 2
  • T. Yoshizaki
    • 1
    • 2
  • S. Makino
    • 1
    • 2
  1. 1.Kanzakigawa Laboratory, Shionogi Research LaboratoriesShionogi & Co., Ltd.Toyonaka-shi, Osaka(Japan)
  2. 2.Aburahi Laboratories, Shionogi Research LaboratoriesShionogi & Co., Ltd.Shiga(Japan)

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