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Experientia

, Volume 45, Issue 11–12, pp 1110–1112 | Cite as

Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues

  • M. Satake
  • Y. Chiba
  • Y. Kohama
  • K. Yamamoto
  • M. Okabe
  • T. Mimura
  • T. Imanishi
  • C. Iwata
Research Articles

Summary

D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

Key words

D-Cysteinolic acid platelet aggregation inhibitor marine product 2-aminoethyl disulfide sardine 

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • M. Satake
    • 1
  • Y. Chiba
    • 1
  • Y. Kohama
    • 2
  • K. Yamamoto
    • 2
  • M. Okabe
    • 2
  • T. Mimura
    • 2
  • T. Imanishi
    • 2
  • C. Iwata
    • 2
  1. 1.Central Research LaboratoryNippon Suisan Co. Ltd.Hachiohji, TokyoJapan
  2. 2.Faculty of Pharmaceutical SciencesOsaka UniversitySuita, OsakaJapan

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