Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam
- 24 Downloads
The basal EEG profile of the aged Fisher-344 rat was consistently different from that of the young rat, showing dominant high voltage slow-wave components. These slow waves were present in both the frontal cerebral cortex and dorsal hippocampus. Absent or greatly attenuated in the aged rat's hippocampal EEG was rhythmic theta activity, which was always dominant in the young awake rat's hippocampus. These EEG differences were clearly apparent only under basal test conditions, i.e, following habituation to the test situation. Pramiracetam sulfate acted strongly to normalize the aged rat's EEG, while the action of piracetam was weak and appeared to undergo tolerance development.
Key wordsPramiracetam sulfate piracetam cognition activator nootropic quantitative EEG arousal or vigilance deficit aged EEG Fisher-344 rat
Unable to display preview. Download preview PDF.
- 1.Bente, D., Glatthaar, G., Ulrich, G., and Lewinsky, M., Arzneimittel-Forsch.28 (1978) 1529.Google Scholar
- 2.Saletu, B., Grünberger, J., and Linzmayer, L., Meth. Find. exp. clin. Pharmac.2 (1980) 269.Google Scholar
- 3.Poschel, B.P.H., Marriott, J.G., and Gluckman, M.I., Drugs exp. clin. Res.IX (1983) 853.Google Scholar
- 4.Butler, D.E., Nordin, I.C., L'Italien, Y.J., Zweisler, L., Poschel, B.P.H., and Marriott, J.G., J. med. Chem.27 (1984) 684.Google Scholar