Experientia

, Volume 37, Issue 12, pp 1341–1343 | Cite as

Pathological changes in inbred strains of mice following early thymectomy and irradiation

  • S. Ansar Ahmed
  • W. J. Penhale
Specialia

Summary

Mice subjected to thymectomy and irradiation were found to develop a range of pathological change in various organs. These changes were accompanied by antibodies to a variety of self-components. The pattern of pathological and autoimmune change was found to vary with the strain. This strain-related expression did not appear to be associated with the major histocompatibility complex (H-2).

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References

  1. 3.
    E. Witebsky and N.R. Rose, J. Immun.76, 408 (1956).PubMedGoogle Scholar
  2. 4.
    P.Y. Paterson, Adv. Immun.5, 131 (1966).PubMedGoogle Scholar
  3. 5.
    P.J. Baker, P.W. Stashak, D.F. Amsbaugh, B.A. Prescott and R.F. Bach, J. Immun.105, 1581 (1970).PubMedGoogle Scholar
  4. 6.
    W.J. Penhale, A. Farmer, R.P. McKenna and W.J. Irvine, Clin. exp. Immun.15, 225 (1973).PubMedGoogle Scholar
  5. 7.
    P. Strastny, J. clin. Invest.57, 1148 (1976).PubMedGoogle Scholar
  6. 8.
    D. Bernoco and P.I. Terasaki, in: Genetic control on autoimmune diseases, p. 3. Ed. N.R. Rose, P.E. Bigazzi and N.L. Warner. Elsevier/North-Holland, Amsterdam 1978.Google Scholar
  7. 9.
    P.J. Morris, H. Vaughan, B.D. Tait and I.R. Mackay, Aust. N.Z.J. Med.7, 616 (1977).PubMedGoogle Scholar
  8. 10.
    A. Svejgaard, P. Platz, L.P. Ryden, L.S. Nielsen and M. Thomsen, Transplant. Rev.22, 3 (1973).Google Scholar
  9. 11.
    K.O. Cox and J.J. Finlay-Jones, Br. J. exp. Path.60, 466 (1979).Google Scholar
  10. 12.
    J. Thivolet, J.C. Monier, J.P. Ruel and M.H. Richard, Nature214, 1134 (1967).PubMedGoogle Scholar
  11. 13.
    A. Kojima, Y. Tanaka-Kojima, T. Sakakura and Y. Nashizuka, Lab. Invest.84, 550 (1976).Google Scholar
  12. 14.
    W.J. Penhale, unpublished observations.Google Scholar
  13. 15.
    W.J. Penhale, W.J. Irvine, J.R. Inglis and A. Farmer, Clin. exp. Immun.25, 6 (1976).PubMedGoogle Scholar
  14. 16.
    S. Ansar Ahmed and W.J. Penhale, Clin. exp. Immun., in press (1981).Google Scholar

Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • S. Ansar Ahmed
    • 1
  • W. J. Penhale
    • 1
  1. 1.Division of Veterinary Biology, School of Veterinary StudiesMurdoch UniversityMurdoch

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