Experientia

, Volume 34, Issue 6, pp 741–742 | Cite as

Effect of chronic alloxan diabetes and insulin administration on intestinal brush border enzymes

  • A. Mahmood
  • R.M. Pathak
  • N. Agarwal
Specialia

Summary

Brush border sucrase and lactase activities are significantly elevated in alloxan-induced chronic diabetes and are restored to control levels after insulin treatment. Alkaline phosphatase and Mg-ATPase levels remain unchanged in diabetes, compared to a control group. Insulin treatment alone to control animals also led to enhanced activities of these enzymes.

Keywords

Enzyme Alkaline Phosphatase Brush Border Insulin Treatment Alloxan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    A.D. Axelrod, A.I. Lawrence and R.L. Hazelwood, Am. J. Physiol.219, 860 (1970).PubMedGoogle Scholar
  2. 2.
    H.P. Schedl and H.P. Wilson, Am. J. Physiol.220, 1739 (1971).PubMedGoogle Scholar
  3. 3.
    D. Lall and H.P. Schedl, Am. J. Physiol.227, 827 (1974).PubMedGoogle Scholar
  4. 4.
    A. Mahmood and A.M. Siddiqi, Indian J. exp. Biol.10, 237 (1972).PubMedGoogle Scholar
  5. 5.
    M.K. Younoszai and H.P. Schedl, J. Lab. clin. Med.79, 579 (1972).PubMedGoogle Scholar
  6. 6.
    W.A. Olsen and L. Rogers, J. Lab. clin. Med.77, 838 (1970).Google Scholar
  7. 7.
    V.P.S. Chauhan and A.K. Sarkar, Experientia33, 22 (1977).CrossRefPubMedGoogle Scholar
  8. 8.
    J. Schmitz, H. Presier, D. Maestracci, B.K. Ghosh, J.J. Cerdo and R.K. Crane, Biochim. biophys. Acta323, 98 (1973).PubMedGoogle Scholar
  9. 9.
    A. Dahlqvist, Enzym. biol. clin.11, 52 (1970).Google Scholar
  10. 10.
    A. Mahmood and F. Alvarado, Archs Biochem. Biophys.168, 585 (1975).CrossRefGoogle Scholar
  11. 11.
    A. Eiccholz, Biochim. biophys. Acta135, 475 (1967).PubMedGoogle Scholar
  12. 12.
    A. Mahmood, K. Singh and A.K. Ahuja, Indian J. Biochem. Biophys.9, 206 (1972).PubMedGoogle Scholar
  13. 13.
    H. Somogyi, J. biol. Chem.100, 12 (1945).Google Scholar
  14. 14.
    O.H. Lowry, N. Rosebrough, A.L. Farr and R.L. Randall, J. biol. Chem.193, 265 (1951).PubMedGoogle Scholar
  15. 15.
    E.L. Jervis and R.J. Levine, Nature210, 391 (1966).PubMedGoogle Scholar
  16. 16.
    R.K. Crane, in: Intracellular Transport, p. 71. Ed. K.B. Warren. Academic Press, New York 1966.Google Scholar
  17. 17.
    D.L. Coleman and D.L. Burkart, Diabetologia13, 25 (1977).CrossRefPubMedGoogle Scholar
  18. 18.
    L.G. Heding and S.M. Rasmussen, Diabetologia8, 408 (1972).CrossRefPubMedGoogle Scholar
  19. 19.
    N.J. Christensen, Diabetes23, 1 (1974).PubMedGoogle Scholar
  20. 20.
    P. Clenano, J. Jumawan, C. Harowitz, H. Lau and O. Koldovsky, Biochem. J.162, 469 (1977).PubMedGoogle Scholar
  21. 21.
    A. Mahmood and S.D. Varma, Z. Gastroent.9, 425 (1971).Google Scholar
  22. 22.
    A. Sols, S. Vidal and L. Larralds, Nature161, 932 (1948).Google Scholar
  23. 23.
    I.G. Wool, Fedn Proc.24, 1060 (1965).Google Scholar
  24. 24.
    D. Miller and R.K. Crane, Biochim. biophys. Acta52, 281 (1961).PubMedGoogle Scholar
  25. 25.
    K. Ramaswamy, P. Malathi and R.K. Crane, Biochem. biophys. Res. Commun.68, 161 (1976).CrossRefGoogle Scholar

Copyright information

© Birkhäuser-Verlag 1978

Authors and Affiliations

  • A. Mahmood
    • 1
  • R.M. Pathak
    • 1
  • N. Agarwal
    • 1
  1. 1.Department of BiochemistryPostgraduate Institute of Medical Education and ResearchChandigarh(India)

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