, Volume 40, Issue 11, pp 1240–1244 | Cite as

Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells

  • M. L. Patchen
  • T. J. MacVittie
  • L. M. Wathen


Glucan, a beta-1, 3 polyglucose, was administered to mice either 1 h before or 1 h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistantly exhibited a more rapid recovery of pluripotent stem cells and committed granulocyte, macrophage, and erythroid progenitor cells. This may partially explain the mechanism by which glucan also enhances survival in otherwise lethally irradiated mice.

Key words

Mice glucan treatment Co60-irradiation stem cells, pluripotent granulocytes macrophages erythroid progenitor cells hemopoietic stomal cells hemopoiesis 


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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • M. L. Patchen
    • 1
  • T. J. MacVittie
    • 1
  • L. M. Wathen
    • 1
  1. 1.Experimental Hematology DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA

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