Experientia

, Volume 33, Issue 8, pp 1036–1037

Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes

  • J. Seubert
  • R. Pohlke
  • F. Loebich
Specialia Biologica
  • 138 Downloads

Summary

Synthesis and properties of 2-cyclohexylcarbonyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino [2,1-a] isoquinolin-4-one, a novel anthelmintic with excellent activity against all species of Schistosomes pathogenic to man and a wide range of cestodes, will be reported.

References

  1. 1a.
    P. J. Islip, in: Progress in Drug Research, vol. 17, p. 241. Birkhäuser Verlag, Basel and Stuttgart 1973.Google Scholar
  2. 1b.
    R. B. Burrows, in: Progress in Drug Research, vol. 17, p. 108. Birkhäuser Verlag, Basel and Stuttgart 1973.Google Scholar
  3. 2.
    T. H. Pesigan, World med. J.14, 18 (1967).PubMedGoogle Scholar
  4. 3.
    H. W. Brown, Clin. Pharmac. Ther.10, 5 (1969).Google Scholar
  5. 4.
    R. Goennert, Münch. med. Wschr.116, 1531 (1974).Google Scholar
  6. 5.
    Jointly developed by E. Merck (Darmstadt) and Bayer AG.Google Scholar
  7. 6.
    Internal designation is EMBAY 8440.Google Scholar
  8. 7.
    J. Seubert, H. Thomas and P. Andrews, German Offenlegungsschrift P 23 62 539.Google Scholar
  9. 8a.
    R. Pohlke, German Offenlegungsschriften P1795728, P2508947.Google Scholar
  10. 8b.
    R. Pohlke, F. Loebich, J. Seubert, H. Thomas and P. Andrews, German Offenlegungsschrift P 23 31713.Google Scholar
  11. 8c.
    J. Seubert, R. Pohlke, H. Thomas and P. Andrews, German Offenlegungsschrift P 2441261.Google Scholar
  12. 8d.
    J. Seubert, German Offenlegungsschriften P 2418111, P 2457971.Google Scholar
  13. 9.
    H. Rupe and W. Frey, Helv. Chim. Acta22, 673 (1939).CrossRefGoogle Scholar
  14. 10.
    J. Seubert, German Offenlegungsschrift P 2504250 .Google Scholar
  15. 11.
    Detailed papers on syntheses and structure-activity relationships of2 will be published elsewhere.Google Scholar
  16. 12.
    P. Andrews, R. Goennert, R. Pohlke and J. Seubert, Abstracts of the Tagung deutschsprachiger tropenmedizinischer Gesellschaften in Lindau, Lake Constance, March 24–26, 1977.Google Scholar
  17. 13.
    A. Davis, Abstracts of the Tagung deutschsprachiger tropenmedizinischer Gesellschaften in Lindau, Lake Constance, March 24–26, 1977.Google Scholar
  18. 14.
    G. Webbe and C. James, Abstracts of the Tagung deutschsprachiger tropenmedizinischer Gesellschaften in Lindau, Lake Constance, March 24–26, 1977.Google Scholar
  19. 15.
    H. Thomas, R. Goennert, R. Pohlke and J. Seubert, Abstracts of the 7th International Conference on Pathophysiology of Parasitic Infections in Thessaloniki, Greece, July 14–16, 1975.Google Scholar
  20. 16.
    M. A. Gemell, P. D. Johnstone and G. Oudemans, Res. vet. Sci. (in press).Google Scholar
  21. 17.
    H. Diekmann, P. Andrews, M. v. Eberstein, H. Frohberg, P. Groning and P. Muermann, a) abstracts of the 7th International Conference on Pathophysiology of Parasitic Infections in Thessaloniki/Greece, July 14–16, 1975 and b) Abstracts of the 2nd European Multicolloquy of Parasitology Trogir, Jugoslavia, September 1975.Google Scholar
  22. 18.
    P. Muermann, M. v. Eberstein and H. Frohberg, Vet. med. Nachr.1976, 142.Google Scholar
  23. 19.
    D. Bankov, Abstracts of the 7th International Conference on Pathophysiology of Parasitic Infections, Thessaloniki, Greece, July 14–16, 1975.Google Scholar
  24. 20.
    A. Dey-Hazra, Vet. med. Nachr.1976, 134.Google Scholar
  25. 21.
    N. Gueralp, Y. Tigin, T. Oguz, R. Tinar and A. Burgu, Vet. Med. Nachr.1976, 129.Google Scholar
  26. 22.
    M. Rommel, H. Grelck and F. Hoerchner, Berl. Münch. Tierärztl. Wschr.89, 255 (1976).Google Scholar
  27. 23.
    T. Wikerhauser, J. Beglez, V. Kuticic and B. Kozelj, Acta parasit. jugosl.7, 33 (1976).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • J. Seubert
    • 1
  • R. Pohlke
    • 1
  • F. Loebich
    • 1
  1. 1.Pharmazeutisch-chemische Forschungslaboratorien, E. MerckDarmstadtFederal Republic of Germany

Personalised recommendations