Experientia

, Volume 33, Issue 8, pp 995–996 | Cite as

Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice

  • T. T. Yen
  • J. A. Allan
  • D. V. Pearson
  • M. R. Schinitsky
Specialia Chimica, Biochimica

Summary

Genetically obese, diabetic and hypercholesterolemic C57BL/6J-ob/ob mice were placed on Purina Laboratory Chow containing 2% cholesterol for up to 4 months. They developed higher plasma cholesterol levels and accumulated an increased quantity of cholesterol in the liver but failed to develop atherosclerotic lesions in the aorta as would be expected in an obese, diabetic and hypercholesterolemic human adult.

References

  1. 2.
    J. Mayer and A. K. Jones, Am. J. Physiol.175, 339 (1953).PubMedGoogle Scholar
  2. 3.
    D. Glick, B. F. Fell and K. Sjølin, Analyt. Chem.36, 1119 (1964).CrossRefGoogle Scholar
  3. 4.
    R. J. Emerson and J. T. Van Bruggen, Archs Biochem. Biophys.77, 467 (1958).CrossRefGoogle Scholar
  4. 5.
    A. Zlatkis, B. Zak and A. J. Boyle, J. Lab. clin. Med.41, 486 (1953).PubMedGoogle Scholar
  5. 6.
    G. R. Jansen, M. E. Zanetti and C. F. Hutchison, Biochem. J.102, 870 (1967).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • T. T. Yen
    • 1
  • J. A. Allan
    • 1
  • D. V. Pearson
    • 1
  • M. R. Schinitsky
    • 1
  1. 1.The Lilly Research LaboratoriesEli Lilly and CompanyIndianapolisUSA

Personalised recommendations