, Volume 42, Issue 7, pp 823–825 | Cite as

The potent tremorgenic neurotoxins lolitrem B and aflatrem: A comparison of the tremor response in mice

  • R. T. Gallagher
  • A. D. Hawkes
Short Communications


Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremorgenic mycotoxin aflatrem. A family of characteristic curves was revealed for each tremorgen, with lolitrem B eliciting a sustained tremor response persisting for over 24 h.

Key words

Tremorgenic neurotoxins indoles lolitrem B aflatrem mice tremor dose-response, ryegrass staggers 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gallagher, R.T., White, E.P., and Mortimer, P.H., N.Z. Vet. J.29 (1981) 189.PubMedGoogle Scholar
  2. 2.
    Gallagher, R.T., Campbell, A.G., Hawkes, A.D., Holland, P.T., McGaveston, D.A., Pansier, E.A., and Harvey, I.C., N.Z. Vet. J.30 (1982) 183.Google Scholar
  3. 3.
    Gallagher, R.T., Hawkes, A.D., and Stewart, J.M., J. Chromat.321 (1985) 217.Google Scholar
  4. 4.
    Gallagher, R.T., and Hawkes, A.D., N.Z. J. agric. Res.28 (1985) 427.Google Scholar
  5. 5.
    Gallagher, R.T., Hawkes, A.D., Steyn, P.S., and Vleggaar, R., J. Chem. Soc. Chem. Commun. (Lond.) (1984) 614.Google Scholar
  6. 6.
    Keogh, R.G., N.Z. J. expl Agric.1 (1973) 55.Google Scholar
  7. 7.
    Gallagher, R.T., Keogh, R.G., Latch, G.C.M. and Reid, C.S.W., N.Z. J. agric. Res.20 (1977) 431.Google Scholar
  8. 8.
    Mantle, P.G., and Penny, R.C., in: The Veterinary Annual, 21st Issue, p. 51. Eds C.S.G. Grunsell and F.W.G. Hill. Scientechnica, J. Wright and Sons, Bristol, England 1981.Google Scholar
  9. 9.
    Mortimer, P.H., Young, P.W., and Dimenna, M.E., Proc. N.Z. Soc. Anim. Prod.44 (1984) 181.Google Scholar
  10. 10.
    Gallagher, R.T., in: Proc. Eighth Congress International Society for Human and Animal Mycology, February 1982, p. 469. Ed. M. Baxter, Massey University, Palmerston North, New Zealand 1983.Google Scholar
  11. 11.
    Munday, B.L., Monkhouse, I.M., and Gallagher, R.T., Aust. Vet. J.62 (1985) 207.Google Scholar
  12. 12.
    Aasen, A.J., Culvenor, C.J., Finnie, E.P., Kellock, A.W., and Smith, L.W., Aust. J. agric. Res.20 (1969) 71.Google Scholar
  13. 13.
    Shreeve, B.J., Patterson, D.S.P., Roberts, B.A., MacDonald, S.M., and Wood, E.N., Vet. Rec.103 (1978) 209.PubMedGoogle Scholar
  14. 14.
    Lanigan, G.W., Payne, A.L., and Cockrum, P.A., Aust. J. expl Biol. med. Sci.57 (1979) 31.Google Scholar
  15. 15.
    Wilson, B.J., and Wilson, C.H., Science144 (1964) 177.PubMedGoogle Scholar
  16. 16.
    Gallagher, R.T., and Wilson, B.J., Mycopathologia66 (1978) 183.Google Scholar
  17. 17.
    Gallagher, R.T., Clardy, J., and Wilson, B.J., Tetrahedron Lett.21 (1980) 239.Google Scholar
  18. 18.
    Cole, R.J., Dorner, J.W., Springer, J.P., and Cox, R.H., J. Agric. Food Chem.29 (1981) 293.Google Scholar
  19. 19.
    Kelly, D.M., and Naylor, R.J., Eur. J. Pharmac.27 (1974) 14.Google Scholar
  20. 20.
    Everett, G.M., Blockus, L.E., and Shepperd, I.M., Science124 (1956) 79.Google Scholar
  21. 21.
    Jenden, D.J., in: Selected Pharmacological Testing Methods, vol. 3, p. 337. Ed. A. Burger, Medicinal Research Series, Marcel Dekker Inc., New York 1968.Google Scholar
  22. 22.
    Cole, R.J., J. Food Protec.44 (1981) 715.Google Scholar
  23. 23.
    Betina, V., in: Mycotoxins: Production, Isolation, Separation and Purification, p. 415. Ed. V. Betina. Elsevier, Amsterdam 1984.Google Scholar
  24. 24.
    Gallagher, R.T., and Hawkes, A.D., J. Chromat.322 (1985) 159.Google Scholar
  25. 25.
    Caujolle, F.M.E., Caujolle, D.H., Cros, S.B., and Calvet, M.-M.J., Ann. N.Y. Acad. Sci.141 (1967) 110.PubMedGoogle Scholar
  26. 26.
    David, N.A., A. Rev. Pharmac.12 (1972) 353.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1986

Authors and Affiliations

  • R. T. Gallagher
    • 1
  • A. D. Hawkes
    • 1
  1. 1.Ruakura Animal Research StationMinistry of Agriculture and FisheriesHamilton(New Zealand)

Personalised recommendations