Experientia

, Volume 44, Issue 10, pp 880–881 | Cite as

Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi

  • E. G. Díaz de Toranzo
  • J. A. Castro
  • B. M. Franke de Cazzulo
  • J. J. Cazzulo
Short Communications

Summary

Epimastigotes ofTrypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazone acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.

Key words

Trypanosoma cruzi benznidazole Chagas' disease American trypanosomiasis chemotherapy 

References

  1. 1.
    Docampo, R., and Moreno, S. N. J., Rev. Biochem. Toxic.7 (1985) 159.Google Scholar
  2. 2.
    Castro, J. A., and Diaz de Toranzo, E. G. D. de, Biomed. Envir. Sci. (1988) in press.Google Scholar
  3. 3.
    Moreno, S. N. J., Docampo, R., Mason, R. P., Leon, W., and Stoppani, A. O. M., Archs Biochem. Biophys.218 (1982) 585.Google Scholar
  4. 4.
    Docampo, R., and Moreno, S. N. J., Rev. infect. Dis.6 (1984) 223.Google Scholar
  5. 5.
    Docampo, R., and Stoppani, A. O. M., Archs Biochem. Biophys.197 (1979) 317.Google Scholar
  6. 6.
    Docampo, R., and Moreno, S. N. J., in: Oxygen Radicals in Chemistry and Biology pp. 749–752. Eds W. Bors, M. Saran and D. Tait. W. de Gruyter, Berlin 1984.Google Scholar
  7. 7.
    Castro, G. D., and Castro, J. A., Toxicology35 (1985) 319.Google Scholar
  8. 8.
    Masana, M., Toranzo, E. G. D. de, and Castro, J. A., Biochem. Pharmac.33 (1984) 1041.Google Scholar
  9. 9.
    Masana, M., Toranzo, E. G. D. de, Rubio, M., and Castro, J. A., Archs int. Pharmacodyn. Ther.276 (1985) 4.Google Scholar
  10. 10.
    Gorla, N., Diaz Gomez, M. I., and Castro, J. A., Archs int. Pharmacodyn. Ther.280 (1986) 22.Google Scholar
  11. 11.
    Toranzo, E. G. D. de, Masana, M., and Castro, J. A., Archs int. Pharmacodyn. Ther.272 (1983) 17.Google Scholar
  12. 12.
    Cazzulo, J. J., Franke de Cazzulo, B. M., Engel, J. C., and Cannata, J. J. B., Molec. Biochem. Parasit.16 (1985) 329.Google Scholar
  13. 13.
    Borst, P., Fase-Fowler, F., Frasch, A. C. C., Hoeijmakers, J. H. J., and Weijers, P. J., Molec. Biochem. Parasit.1 (1980) 221.Google Scholar
  14. 14.
    Diaz Gomez, M. I., Castro, J. A., Ferreyra, E. C. de, D'Acosta, N., and Castro, C. R. de, Toxic. appl. Pharmac.25 (1973) 534.Google Scholar
  15. 15.
    Castro, J. A., and Diaz Gomez, M. I., Toxic. appl. Pharmac.23 (1972) 541.Google Scholar
  16. 16.
    Villarruel, M. C., and Castro, J. A., Biochem. biophys. Res. Commun.54 (1973) 108.Google Scholar
  17. 17.
    De Boiso, J. F., and Stoppani, A. O. M., Proc. Soc. exp. Biol. Med.136 (1971) 215.Google Scholar
  18. 18.
    Agosin, M., Naquira, C., Paulin, J., and Capdevila, J., Science194 (1976) 195.Google Scholar
  19. 19.
    Kuwahara, T., White, R. A., and Agosin, M., Biochem. biophys. Res. Commun.124 (1984) 121.Google Scholar
  20. 20.
    Aguilar, E. G., Arranz, C. K. de, Toranzo, E. G. D. de, and Castro, J. A., Res. Commun. Chem. Path. Pharmac.50 (1985) 443.Google Scholar
  21. 21.
    Polak, A., and Richle, R., Ann. trop. Med. Parasit.72 (1978) 45.Google Scholar
  22. 22.
    Goijman, S. G., and Stoppani, A. O. M., Biochem. Pharmac.34 (1985) 1331.Google Scholar
  23. 23.
    Goijman, S. G., Frasch, A. C. C., and Stoppani, A. O. M., Biochem. Pharmac.34 (1985) 1457.Google Scholar
  24. 24.
    Castro, J. A., Proc. Iuphar 9th Int. Congress of Pharmac. pp. 243–250. Macmillan, London 1984.Google Scholar
  25. 25.
    Gillette, J. R., and Brodie, B. B., A. Rev. Pharmac.,14 (1974) 271.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • E. G. Díaz de Toranzo
    • 1
  • J. A. Castro
    • 1
  • B. M. Franke de Cazzulo
    • 2
  • J. J. Cazzulo
    • 2
  1. 1.Centro de Investigaciones Toxicológicas (CEITOX)CITEFA/CONICETVilla Martelli, Pcia de Buenos Aires(Argentina)
  2. 2.Instituto de Investigaciones Bioquímicas Fundción CampomarBuenos Aires(Argentina)

Personalised recommendations