The Journal of Membrane Biology

, Volume 37, Issue 1, pp 347–359

Influence of lithium upon the intracellular potential of frog skin epithelium

  • Wolfram Nagel

DOI: 10.1007/BF01940939

Cite this article as:
Nagel, W. J. Membrain Biol. (1977) 37: 347. doi:10.1007/BF01940939


The effect of Li upon the intracellular potential of frog skin (Rana esculenta) was investigated. In the range between 1 and 25mm Li in the epithelial bathing solution, a semilogarithmic linear relationship between [Li] and intracellular potential under short circuit conditions was obtained. The intracellular potential at all [Li] is quantitatively sufficient to explain the previously reported accumulation of Li in the intracellular space of the frog skin epithelium (Leblanc, G. 1972.Pfluegers Arch.337:1) on the basis of a passive entrance step at the outer border. A reduction of the intracellular potential by Li is also observed in the presence of 6mm Na in the epithelial bathing solution. Consequences regarding the mechanism of uptake of Na across the outer border of the frog skin are discussed.

Key words

Frog skin intracellular potential lithium sodium transport amiloride 

Copyright information

© Springer-Verlag New York Inc 1977

Authors and Affiliations

  • Wolfram Nagel
    • 1
  1. 1.Department of PhysiologyUniversity of MunichMunich 2Germany

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