Experientia

, Volume 43, Issue 4, pp 402–403

A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

  • S. Burstein
  • S. A. Hunter
  • V. Latham
  • L. Renzulli
Short Communications

Summary

The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of Δ1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.

Key words

Δ1-tetrahydrocannabinol metabolites antagonists 

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • S. Burstein
    • 1
  • S. A. Hunter
    • 1
  • V. Latham
    • 1
  • L. Renzulli
    • 1
  1. 1.Department of BiochemistryUniversity of Massachusetts Medical SchoolWorcesterUSA

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