Experientia

, Volume 43, Issue 4, pp 395–397 | Cite as

Inactivation of sarin and soman by cyclodextrins in vitro

  • B. Désiré
  • S. Saint-André
Short Communications

Summary

Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for β-cyclodextrin than for α- or γ-cyclodextrins. Thus β-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.

Key words

Nerve agents sarin soman tabun VX cyclodextrin 

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • B. Désiré
    • 1
  • S. Saint-André
    • 1
  1. 1.Division de Chimie et PharmacologieCentre de Recherches du Service de Santé des ArméesLyon Cedex 03(France)

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