Experientia

, Volume 44, Issue 11–12, pp 993–996

Azelastine inhibits bronchial hyperreactivity to acetylcholine in guinea pigs

  • U. Achterrath-Tuckermann
  • I. Szelenyi
Short Communications

Summary

Contractile responses to acetylcholine were measured using isolated tracheae obtained from actively sensitized guinea pigs 0.5, 1, 5, 20, 24, 48 and 72 h after antigen challenge. Tracheal contractions to acetylcholine and to histamine were significantly increased 20 h but not 0.5, 1, 5, 24, 48 and 72 h after antigen challenge indicating bronchial hyperreactivity. When animals were pretreated with azelastine and then exposed to antigen challenge, concentration-response curve to acetylcholine did not differ from that obtained in control (non-challenged) tracheae. It is likely that azelastine is able to inhibit bronchial hyperresponsiveness to chemical mediators of bronchial asthma.

Key words

Guinea pig active immunisation in vitro acetylcholine azelastine hyperreactivity trachea contraction 

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Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • U. Achterrath-Tuckermann
    • 1
  • I. Szelenyi
    • 1
  1. 1.Department of PharmacologyASTA Pharma AGFrankfurt/Main 1(Federal Republic of Germany)

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