, Volume 44, Issue 11–12, pp 983–987 | Cite as

Nonlinear dynamics in sudden cardiac death syndrome: Heartrate oscillations and bifurcations

  • A. L. Goldberger
  • D. R. Rigney
  • J. Mietus
  • E. M. Antman
  • S. Greenwald
Short Communications


Patients at high risk of sudden cardiac death show evidence of nonlinear heartrate dynamics, including abrupt spectral changes (bifurcations) and sustained low frequency (.01–.04 Hz) oscillations in heartrate.

Key words

Autonomic nervous system electrocardiography fractals heart failure nonlinear dynamics ventricular fibrillation ventricular tachycardia 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Willerson, J. T., in: Cecil Textbook of Medicine, 16th edn., p. 256. Eds J. B. Wyngaarden, and L. H. Smith Jr. W. B. Saunders Co., Philadelphia 1982.Google Scholar
  2. 2.
    Goldberger, A. L., Findley, L. J., Blackburn, M. J., and Mandell, A. J., Am. Heart J.107 (1984) 612.CrossRefPubMedGoogle Scholar
  3. 3.
    Goldberger, A. L., and West, B. J., Ann. N. Y. Acad. Sci.504 (1987) 195.PubMedGoogle Scholar
  4. 4.
    Goldberger, A. L., and West, B. J., Yale J. biol. Med.60 (1987) 421.PubMedGoogle Scholar
  5. 5.
    Goldberger, A. L., and Rigney, D. R., Proc. Ninth Ann. Cong. IEEE Eng. med. Biol. Soc.1 (1987) 313.Google Scholar
  6. 6.
    Baim, D. S., Colucci, W. S., Monrad, E. S., et al., J. Am. Coll. Cardiol.7 (1986) 661.PubMedGoogle Scholar
  7. 7.
    Sayers, B. McA., Ergonomics16 (1973) 17.PubMedGoogle Scholar
  8. 8.
    Kitney, R. I., and Rompelman, O. Eds, The Study of Heart Rate Variability. Clarendon Press, Oxford 1980.Google Scholar
  9. 9.
    Akselrod, S., Gordon, D., Shannon, D., et al. Science213 (1981) 220.PubMedGoogle Scholar
  10. 10.
    Kobayashi, M., and Musha, T., 1/f fluctuation of heartbeat period. IEEE Trans. Biomed. Eng.29 (1982) 456.PubMedGoogle Scholar
  11. 11.
    Guevara, M. R., Glass, L., and Shrier, A., Science214 (1981) 1350.PubMedGoogle Scholar
  12. 12.
    Goldberger, A. L., Bhargava, V., West, B. J. and Mandell, A. J., Physica17D (1985) 207.Google Scholar
  13. 13.
    Ritzenberg, A. L., Adam, D. R., and Cohen, R. J., Nature307 (1984) 159.CrossRefPubMedGoogle Scholar
  14. 14.
    Goldberger, A. L., Shabetai, R., Bhargava, V., et al., Am. Heart J.107 (1984) 1297.CrossRefPubMedGoogle Scholar
  15. 15.
    Guyton, A. C., Crowell, J. W., and Moore, J. W., Am. J. Physiol.187 (1956) 395.PubMedGoogle Scholar
  16. 16.
    Mackey, M. C., and Glass, L., Science197 (1977) 287.PubMedGoogle Scholar
  17. 17.
    Martin, G. J., Magid, N. M., Myers, G., et al., Am. J. Cardiol.60 (1987) 86.CrossRefPubMedGoogle Scholar
  18. 18.
    Klieger, R. E., Miller, J. P., Bigger, J. T. Jr. et al. Am. J. Cardiol.59 (1987) 265.Google Scholar
  19. 19.
    Freeman, R. K., and Garite, T. J., Fetal Heart Rate Monitoring, pp. 7–18 89–112. Williams & Wilkins, Baltimore 1981.Google Scholar
  20. 20.
    Kolman, B. S., Verrier, R. L., and Lown, B., Am. J. Cardiol.37 (1975) 1041.CrossRefGoogle Scholar
  21. 21.
    Findley, L. J., Blackburn, M. R., Goldberger, A. L., and Mandell, A. J., Am. Rev. respir. Dis.130 (1984) 937.PubMedGoogle Scholar
  22. 22.
    Glass, L. Goldberger, A. L., Courtemanche, M., and Shrier, A. Proc. R. Soc. Lond. A413 (1987) 9.Google Scholar
  23. 23.
    Saul, J. P., personal communication.Google Scholar

Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • A. L. Goldberger
    • 1
  • D. R. Rigney
    • 1
    • 3
  • J. Mietus
    • 1
  • E. M. Antman
    • 2
  • S. Greenwald
    • 3
  1. 1.Cardiovascular DivisionBeth Israel Hospital & Harvard Medical SchoolBoston
  2. 2.Cardiovascular DivisionBrigham and Women's Hospital & Harvard Medical SchoolBoston
  3. 3.Harvard-MIT Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA

Personalised recommendations