, Volume 32, Issue 11, pp 1467–1468

The origin of experimental brain tumours: A sequential study

  • P. L. Lantos
  • D. J. Cox
Anatomica, Histologica, Embryologica, Carcinologica


A sequential study of rat brains treated transplacentally with the neurotropic carcinogen ethylnitrosourea reveals small foci of cell proliferations from the age of 8 weeks. These lesions consist mainly of undifferentiated cells of the subependymal plate type. They occur in those areas in which gliomas develop and represent the earliest, histologically detectable, changes in the development of brain tumours.


  1. 2.
    H. Druckrey, S. Ivankovic andR. Preussmann, Nature, Lond.210, 1378 (1966).Google Scholar
  2. 3.
    S. Ivankovic andH. Druckrey, Z. Krebsforsch.71, 320 (1968).PubMedGoogle Scholar
  3. 4.
    H. Druckrey, R. Preussmann, S. Ivankovic andD. Schmähl, Z. Krebsforsch.69, 103 (1967).PubMedGoogle Scholar
  4. 5.
    E. L. Jones, C. E. Searle andW. Thomas Smith, J. Path.109, 123 (1973).PubMedGoogle Scholar
  5. 6.
    A. Koestner, J. W. Swenberg andW. Wechsler, Am. J. Path.63, 37 (1971).PubMedGoogle Scholar
  6. 7.
    J. A. Swenberg, N. Clendenon, R. Denlinger andW. A. Gordon, J. natn. Cancer Inst.55, 147 (1975).Google Scholar
  7. 8.
    W. Wechsler, P. Kleihues, S. Matsumoto, K. J. Zülch, S. Ivankovic, R. Preussmann andH. Druckrey, Ann. N. Y. Acad. Sci.159, 360 (1969).Google Scholar
  8. 9.
    P. Kleihues, P. L. Lantos andP. N. Magee, Int. Rev. exp. Path.15, 153 (1976).PubMedGoogle Scholar
  9. 10.
    W. F. Blakemore, J. Anat.104, 423 (1969).PubMedGoogle Scholar
  10. 11.
    P. L. Lantos, J. neurol. Sci.17, 433 (1972).Google Scholar
  11. 12.
    P. N. Magee, Food Cosmet. Toxic.9, 207 (1971).Google Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • P. L. Lantos
    • 1
  • D. J. Cox
    • 1
  1. 1.Department of Neurological Studies and Bland-Sutton Institute of PathologyMiddlesex Hospital Medical SchoolLondonEngland

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