, Volume 33, Issue 1, pp 70–71 | Cite as

The local anesthetic potency of norcocaine, a metabolite of cocaine

  • W. W. Just
  • J. Hoyer


The local anesthetic effects of cocaine and one of its main metabolites norcocaine, were investigated comparatively on isolated ganglion cells of the marine gastropod,Aplysia californica. During a 1-hour-period, different action potential parameters such as amplitude, duration, maximum rate of rise were observed, which demonstrated that norcocaine exhibits a higher local anesthetic potency than cocaine.


Cocaine Ganglion Cell Maximum Rate Local Anesthetic Effect Potential Parameter 
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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • W. W. Just
    • 1
    • 2
  • J. Hoyer
    • 1
    • 2
  1. 1.Arbeitsgruppe NeurochemieMax-Planck-Institut für HirnforschungFrankfurt a. M.Federal Republic of Germany, BRD
  2. 2.Institut für allgemeine und vergleichende Physiologie der Universität WienWienAustria

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