Experientia

, Volume 46, Issue 8, pp 856–860 | Cite as

Increased angiogenesis in diabetes

  • K. Norrby
  • A. Jakobsson
  • M. Simonsen
  • J. Sörbo
Research Articles
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Accepted:

Summary

Rats with streptozotocin-induced diabetes mellitus showed a 3.4–4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two idependent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions.

Key words

Angiogenesis diabetes mast cells mesentery quantification rat 
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Copyright information

© Birkhäuser Verlag Basel 1990

Authors and Affiliations

  • K. Norrby
    • 1
  • A. Jakobsson
    • 1
  • M. Simonsen
    • 1
  • J. Sörbo
    • 1
  1. 1.Department of PathologyGothenburg University, Sahlgren's HospitalGothenburgSweden

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