The Journal of Membrane Biology

, Volume 77, Issue 2, pp 93–99 | Cite as

Axonal microtubules necessary for generation of sodium current in squid giant axons: II. Effect of colchicine upon asymmetrical displacement current

  • Gen Matsumoto
  • Michinori Ichikawa
  • Akira Tasaki


Effect of internal colchicine on asymmetrical displacement currents was studied by internally perfusing squid giant axons with a solution containing colchicine. It was found that (1) asymmetrical displacement currents were composed of two parts; colchicine-sensitive and colchicine-resistant; that (2) the colchicine-sensitive part had a definite rising phase while the colchicine-resistant one showed an instantaneous jump, followed by exponential decay; and that (3) the colchicine-sensitive part related to normal Na channels.

Key Words

Na gating currents Na currents colchicine 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Gen Matsumoto
    • 1
  • Michinori Ichikawa
    • 1
  • Akira Tasaki
    • 1
  1. 1.Electrotechnical Laboratory, Tsukuba Science CityIbarakiJapan
  2. 2.Institute of Applied PhysicsThe University of Tsukuba, Tsukuba Science CityIbarakiJapan

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