Experientia

, Volume 50, Issue 11–12, pp 1012–1020

BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum

  • I. G. Haas
Multi-Author Reviews

Abstract

BiP is a constitutively-expressed resident protein of the endoplasmic, reticulum (ER) of all eucaryotic cells, and belongs to the highly conserved hsp70 protein family. In the ER, BiP is involved in polypeptide translocation, protein folding and presumably protein degradation as well. These functions are essential to cell viability, as has been shown for yeast. In this review, I will summarize the structural features of hsp70 proteins and focus on those experiments which revealed the biological function of BiP.

Key words

ER-translocation folding and assembly of polypeptide chains hsp70 structure ER-degradation 

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Copyright information

© Birkhäuser Verlag Basel 1994

Authors and Affiliations

  • I. G. Haas
    • 1
  1. 1.Institut für Biochemie der Universität HeidelbergHeidelberg(Germany)

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