, Volume 31, Issue 12, pp 1475–1476 | Cite as

A rapid method for the verification of drug injection into the cerebral ventricular system of the rat

  • A. Hernandez
  • S. Ruiz
  • C. Paeile
Pro Experimentis


A precise method for the injection of drugs into the cerebroventricular system of small animals used for experimentation is described. This method, based on the intraventricular pressure record, gives absolute certainty for the injection of a drug into a previously selected site and thus avoids the subsequent histological studies.


Small Animal Histological Study Drug Injection Rapid Method Precise Method 
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  1. 1.
    W. Feldberg andS. L. Sherwood, J. Physiol., Lond.120, 3 (1953).Google Scholar
  2. 2.
    J. Glowinski, I. J. Kopin andJ. Axelrod, J. Neurochem.12, 25 (1965).PubMedGoogle Scholar
  3. 3.
    L. E. McCarthy andH. L. Borison, Anat. Rec.155, 305 (1966).PubMedGoogle Scholar
  4. 4.
    K. M. Taylor andR. Laverty, J. Neurochem.16, 1361 (1969).PubMedGoogle Scholar
  5. 5.
    T. J. Haley andW. C. McCornick, Br. J. Pharmac.12, 12 (1957).Google Scholar
  6. 6.
    E. P. Noble, R. J. Wurtmann andJ. A. Axelrod, Life Sci.6, 281 (1967).PubMedGoogle Scholar
  7. 7.
    S. M. Schanberg, J. Schildkraut andI. J. Kopin, J. Pharmac. exp. Ther.157, 311 (1967).Google Scholar
  8. 8.
    J. P. Chalmers andR. J. Wurtmann, J. Pharmac. exp. Ther.178, 8 (1971).Google Scholar
  9. 9.
    K. Albus, M. Schott andA. Herz, Eur. J. Pharmac.12, 53 (1970).Google Scholar
  10. 10.
    L. J. Pellegrino andA. J. Cushmann,A Stereotaxic Atlas of the Rat Brain (Apleton Century-Crofts, New York 1967), figure 80.Google Scholar

Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • A. Hernandez
    • 1
    • 2
  • S. Ruiz
    • 1
    • 2
  • C. Paeile
    • 1
    • 2
  1. 1.Departmento de Ciencias Quimicas y FisiologicasUniversidad de ChileSantiago(Chile)
  2. 2.Departmento de FarmacologiaUniversidad de ChileSantiago(Chile)

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