Experientia

, Volume 34, Issue 3, pp 384–385

Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities

  • H. Vapaatalo
  • Inge-Britt Lindén
  • T. Metsä-Ketelä
  • M. Kangasaho
  • K. Laustiola
Specialia

DOI: 10.1007/BF01923050

Cite this article as:
Vapaatalo, H., Lindén, IB., Metsä-Ketelä, T. et al. Experientia (1978) 34: 384. doi:10.1007/BF01923050

Summary

Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1–0.5 mM, but inhibited by higher concentrations.

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • H. Vapaatalo
    • 1
    • 2
  • Inge-Britt Lindén
    • 1
    • 2
  • T. Metsä-Ketelä
    • 1
    • 2
  • M. Kangasaho
    • 1
    • 2
  • K. Laustiola
    • 1
    • 2
  1. 1.Department of Biomedical SciencesUniversity of TampereTampere 10
  2. 2.Research Laboratories of Medica LtdHelsinki 51(Finland)

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