Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities
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- Vapaatalo, H., Lindén, IB., Metsä-Ketelä, T. et al. Experientia (1978) 34: 384. doi:10.1007/BF01923050
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Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1–0.5 mM, but inhibited by higher concentrations.