Experientia

, Volume 34, Issue 9, pp 1169–1170 | Cite as

High-affinity binding ofβ-alanine to cerebral synaptosomes might involve glycine-receptors

  • F. V. DeFeudis
  • L. M. Orensanz Muñoz
  • M. A. Vidal
  • G. Corrochano
  • M. Sanchez del Alamo
Article
  • 7 Downloads

Summary

High-affinity, Na+-independent binding of β-alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other α-amino acids, but not by taurine or GABA. This binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both β-alanine and glycine.

Keywords

Glycine Taurine Bicuculline Binding Mechanism Strychnine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • F. V. DeFeudis
    • 1
    • 2
  • L. M. Orensanz Muñoz
    • 1
    • 2
  • M. A. Vidal
    • 1
    • 2
  • G. Corrochano
    • 1
    • 2
  • M. Sanchez del Alamo
    • 1
    • 2
  1. 1.Centre de NeurochimieStrasbourg Cédex(France)
  2. 2.Facultad de MedicinaUniversidad Autonoma and Centro ‘Ramón y Cajal’Madrid(Spain)

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