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Experientia

, Volume 29, Issue 11, pp 1368–1369 | Cite as

A comparison of the pharmacological activity in man of intravenously administered 1368-11368-11368-1, cannabinol, and cannabidiol

  • M. Perez-Reyes
  • Martha C. Timmons
  • K. H. Davis
  • E. M. Wall
Specialia

Keywords

Pharmacological Activity Cannabidiol Cannabinol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Resumen

Se hizo un estudio comparativo de la actividad delΔ9-tetrahidrocannabinol, cannabinol, y cannabidiol en producir efectos similares a la marihuana cuando son inyectados i.v. a humanos. Estas substancias son los componentes predominantes de la marihuana o del hashish. Se encontro que a las dosis inyectados cannabidiol no tiene ninguna potencia, y que cannabinol es capaz de producir efectos tipicos de la marihuana, aunque a dosis varias veces mas grandes que las delΔ9-tetrahidrocannabinol.

Literatur

  1. 1.
    R. Mechoulam, A. Shani, H. Edery andY. Grunfeld,169, 611 (1970).Google Scholar
  2. 2.
    M. Perez-Reyes, M. C. Timmons, M. A. Lipton K. H. Davis andM. E. Wall, Science177, 633 (1972).PubMedGoogle Scholar
  3. 3.
    Acknowledgments. These studies were conducted under Contract No. HSM-42-71-95 between the Center for Studies of Narcotic and Drug Abuse of the Division of Narcotic Addiction and Drugo Abuse, NIMH, and the Research Triangle Institute. In addition, this investigation was supported by Public Health Service Research Grant No. RR-46 from the General Clinical Research Centers Branch of the Division of Research Resources. We thank Drs.Monique Braude andS. Szara, Center for Studies of Narcotic and Drug Abuse, NIMH, for their interest and encouragement of this program. We also thankCarolyn Bishop andDaynise Skeen for their technical assistance.Google Scholar

Copyright information

© Birkhäuser Verlag 1973

Authors and Affiliations

  • M. Perez-Reyes
    • 1
    • 2
  • Martha C. Timmons
    • 1
    • 2
  • K. H. Davis
    • 1
    • 2
  • E. M. Wall
    • 1
    • 2
  1. 1.Department of PsychiatryUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Research Triangle InstituteResearch Triangle ParkUSA

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