Experientia

, Volume 33, Issue 4, pp 413–415 | Cite as

Further perhydroazulene diterpenes from marine organisms

  • B. Danise
  • L. Minale
  • R. Riccio
  • V. Amico
  • G. Oriente
  • M. Piattelli
  • C. Tringali
  • E. Fattorusso
  • S. Magno
  • L. Mayol
Specialia

Summary

3 novel diterpenes,4–6, having the perhydroazulene skeleton already found in pachydictiol A (1) and dictyol A (2) and B (3), have been isolated from both the digestive gland of Aplysia depilans and algae of the family Dictyotaceae.

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References

  1. 1.
    D. R. Hirschfeld, W. Fenical, G. H. Y. Lin, R. M. Wing, P. Radlick and J. J. Sims, J. Am. chem. Soc.95, 4049 (1973).Google Scholar
  2. 2.
    L. Minale and R. Riccio, Tetrahedron Lett.1976, 2711.Google Scholar
  3. 3.
    E. Fattorusso, S. Magno, L. Mayol, C. Santacroce, D. Sica, V. Amico, G. Oriente, M. Piattelli and C. Tringali, J. C. S. Chem. Commun.1976, 575.Google Scholar
  4. 4.
    20 g of crude extract from the digestive glands of 3 adult sea hares yielded 170 mg of dictyol C (4) and 250 mg of dictyol D (5);4 and5 were also obtained from D. dichotoma in 0.1 and 0.01% yield of the dry material, respectively; D, ligutatus furnished dictyol E (6) in 0.5% yield.Google Scholar
  5. 5.
    Mass spectral data;4, m/e 306 (2, M+), 288 (18), 270 (49), 177 (71), 175 (51), 159 (47) and 69 (100);5, m/e 304 (3, M+), 286 (2), 268 (3), 175 (7), 173 (6), 157 (10) and 69 (100).Google Scholar
  6. 6.
    J. B. Stothers, in: Carbon-13 NMR Spectroscopy. Academic Press, New York 1972; C. Konno and H. Hikino, Tetrahedron32, 325 (1976).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • B. Danise
    • 1
    • 2
    • 3
  • L. Minale
    • 1
    • 2
    • 3
  • R. Riccio
    • 1
    • 2
    • 3
  • V. Amico
    • 1
    • 2
    • 3
  • G. Oriente
    • 1
    • 2
    • 3
  • M. Piattelli
    • 1
    • 2
    • 3
  • C. Tringali
    • 1
    • 2
    • 3
  • E. Fattorusso
    • 1
    • 2
    • 3
  • S. Magno
    • 1
    • 2
    • 3
  • L. Mayol
    • 1
    • 2
    • 3
  1. 1.Laboratorio per la Chimica di Molecole di Interesse Biologico del C. N. R.Napoli(Italy)
  2. 2.Istituto di Chimica OrganicaUniversità di CataniaCatania(Italy)
  3. 3.Istituto di Chimica OrganicaUniversità di NapoliNapoli(Italy)

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