, Volume 52, Issue 3, pp 239–241 | Cite as

L-arginine and pancreatic islet blood flow in anesthetized rats

  • A. M. Svensson
  • L. Jansson
Research Articles


The aim of the present study was to see if L-arginine, which induces insulin release and is a precursor of the endothelial-derived relaxing factor nitric oxide, affects whole pancreatic and/or islet blood flow. For this purpose, anesthetized male Sprague-Dawley rats were injected intravenously with either saline or L-arginine (25, 100 or 250 mg/kg body weight). All doses of arginine caused a slight increase in blood glucose concentration, while the highest dose (250 mg/kg body weight) also increased insulin concentration. However, no changes in either mean arterial blood pressure, whole pancreatic or islet blood flow could be discerned with any of the doses of arginine used. It is concluded that insulin release is not necessarily associated with an increased islet blood perfusion.

Key words

Pancreatic islets islet blood flow arginine insulin secretion 


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Copyright information

© Birkhäuser Verlag 1996

Authors and Affiliations

  • A. M. Svensson
    • 1
  • L. Jansson
    • 1
  1. 1.Department of Medical Cell BiologyUppsala University, Biomedical CenterUppsalaSweden

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