Annals of Hematology

, Volume 71, Issue 4, pp 181–183 | Cite as

Acquired pure red cell aplasia: a study of six cases

  • F. Gilsanz
  • J. A. Garcia Vela
  • J. A. Vargas
  • J. Ibañez
  • F. Oña
  • J. López
  • M. Roggendorf
Original Article


Persistent infection by parvovirus B19 associated with pure red cell aplasia (PRCA) has been documented in immunocompromised patients. Bone marrow failure is associated with conditions in which immune surveillance is impaired, and in these instances occult parvovirus infection may be suspected. In this study we have assessed by serological and molecular methods whether parvovirus B19 infection may be a more frequent cause of PRCA than hitherto suspected and whether it may be present in the absence of a typical bone marrow picture. Six patients with PRCA — two with isolated PRCA and no apparent underlying disease, two with a lymphoproliferative disease, one with thymoma, and one with chronic myelomonocytic leukemia — have been studied. Four of the six patients had overt PCRA and were clearly immunocompromised. Parvovirus B19 was not detected in any of the six patients by PCR analysis and serology investigating the presence of IgM or IgG antibodies. Although parvovirus B19 infection needs to be ruled out in PRCA it represents only one, and probably not the most frequent, etiological factor of PRCA.

Key words

Parvovirus Anemia Aplasia 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • F. Gilsanz
    • 1
  • J. A. Garcia Vela
    • 2
  • J. A. Vargas
    • 3
  • J. Ibañez
    • 1
  • F. Oña
    • 2
  • J. López
    • 4
  • M. Roggendorf
    • 5
  1. 1.Department of Hematology, Hospital 12 de OctubreUniversidad ComplutenseMadridSpain
  2. 2.Department of HematologyHospital Universitario de GetafeMadridSpain
  3. 3.Department of Internal Medicine, Clínica Puerta de HierroUniversidad AutonomaMadridSpain
  4. 4.Department of Hematology, Hospital Ramon y CajalUniversidad de Alcala de HenaresMadridSpain
  5. 5.Institut für Medizinische VirologieUniversitätsklinikumEssenGermany

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