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Basic Research in Cardiology

, Volume 81, Issue 1, pp 20–28 | Cite as

Circulating and tissue catecholamines in rats with chronic neurogenic hypertension

  • P. Dominiak
  • F. Kees
  • H. Grobecker
Article

Summary

To study the role of peripheral catecholamines in plasma and different tissues in neurogenic hypertension we measured directly blood pressure, maximum rate of left ventricular pressure rise (dp/dtmax) and heart rate through an aortic catheter 5 weeks after total sino-aortic baroreceptor deafferentation in male Sprague-Dawley rats. Blood samples were collected through the same catheter to determine plasma catecholamine concentrations. Blood pressure and dp/dtmax were significantly higher in neurogenic-hypertensive rats when compared with sham operated rats. Plasma noradrenaline concentrations and plasma adrenaline concentrations reached significantly higher levels in neurogenic-hypertensive rats. In the heart noradrenaline content was lower (when calculated per g wet weight) and in the adrenal medulla adrenaline content was higher in neurogenic-hypertensive rats, when compared with sham operated controls. A significant positive correlation was found between dp/dtmax and plasma noradrenaline concentrations.

It is concluded that sino-aortic baroreceptor deafferentation produces a significant chronic hypertension, probably supported by elevated plasma catecholamine concentrations and enhanced synthesis and release of adrenaline from adrenal medulla.

Key words

neurogenic hypertension rats haemodynamics catecholamines tissue plasma 

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Copyright information

© Dr. Dietrich Steinkopff Verlag 1986

Authors and Affiliations

  • P. Dominiak
    • 1
  • F. Kees
    • 1
  • H. Grobecker
    • 1
  1. 1.Lehrstuhl für PharmakologieUniversität RegensburgRegensburgFRG

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