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Small-cell lung cancer and immunochemotherapy withPropionibacterium granulosum KP 45

Summary

Seventy-nine patients with small-cell lung cancer were treated with vincristin, methotrexate, and cyclophosphamide in inductive therapy and with methotrexate, cyclophosphamide, and procarbazine in maintenance therapy. Patients were divided at random into two groups: one group received chemotherapy alone and the second group was additionally subjected to systemic immunotherapy withPropionibacterium granulosum strain KP-45. In general, differences in the frequency of therapy response and in duration of remission could not be stated between the two groups of patients, but patients responding to chemotherapy showed a significantly longer remission time and lower complication rates. This benificial effect of chemoimmunotherapy is not related to a direct antitumor activity of the immunomodifier used, but to the lowered risk of myelosuppression and infections. Immunomodulation in combination with chemo- and/or radiotherapy can be recommended for the treatment of small-cell lung cancer.

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References

  1. Adlam C, Broughton ES, Scott MT (1972) Enhanced resistance of mice to infection with bacteria following pretreatment with Corynebacterium parvum. Nature 235:219–220

  2. Amery WK (1978) Final results of multicenter placebo-controled levamisole study of resectable lung cancer. Cancer Treat Rep 62:1677–1683

  3. Anthony HM, Meams AJ, Mason MK (1979) Levamisole and surgery in bronchial carcinoma patients: Increase in deaths from cardiorespiratory failure. Thorax 34:4–12

  4. Bomford R (1975) Active specific immunotherapy of mouse methylcholanterne induced tumours with Corynebacterium and irradiated tumour cells. Br J Cancer 32:551–557

  5. Castro JE (1974) Antitumour effect of Corynebacterium parvum in mice. Eur J Cancer 10:115–121

  6. Cerutti I (1975) Antiviral properties of Corynebacterium parvum. In: Corynebacterium parvum — Application in experimental and clinical oncology. Plenum Press, New York, pp 84–90

  7. Chare MJB, Baum M (1978) The effect of Corynebacterium parvum on proliferation of monocyte precursors in the bone marrow in mice. Dev Biol Stand 38:195–200

  8. Cohen MH, Chretien PB, Ihde DC (1979) Tymosin fraction V and intensive combination chemotherapy. Prolongation the survival of patients with small cell lung cancer. JAMA 241:1813–15

  9. Edwards FR, Whitwell F (1978) Use of BCG as an immunostimulant in the surgical treatment of carcinoma of the lung, a five year follow-up report. Thorax 33:250–252

  10. Foster J (1978a) Altered toxicity of 5-fluorouracil following treatment with Corynebacterium parvum. Cancer Res 38:850–858

  11. Foster J (1978b) Effect of Corynebacterium parvum on the proliferative rate of granulocyte-macrophage progenitor cells and the toxicity of chemotherapy. Cancer Res 38:2666–2672

  12. Gil J, Orlowski T, Nowakowski W, Ko HL, Roszkowski K, Roszkowski W, Szmigielski S, Pulverer G, Jeljaszewicz J (1980) Local immunotherapy of stomach and intestinal carcinoma by Propionibacterium granulosum. Dis Colon Rectum 23:536–543

  13. Halpern BN, Prevot AR, Biozzi G, Stiffel G, Mouton D, Morard JC, Bouthilleir Y, Decreusfound C (1964) Stimulation de l'activité phagocytaire du systéme reticuloendothelial provoquée par Corynebacterium parvum. Res J Rethiculoendothel Soc 1:77–96

  14. Halpern BN, Biozzi G, Stiffel G, Mouton D (1966) Inhibition of tumour growth by administration of killed Corynebacterium parvum. Nature 212:853–854

  15. Israel L (1975) Report of 414 cases of human tumours treated with corynebacteria. In: Corynebacterium parvum — Application in experimental and clinical oncology. Plenum Press, New York, pp 389–401

  16. McKneally MD, Marer C, Kausel HW (1976) Regional immunotherapy of lung cancer with intrapleural BCG. Lancet 1:377–379

  17. Nathanson L (1977) Immunology and immunotherapy of human breast cancer. Cancer Immunol Immunother 2:209–224

  18. Pinsky C, De Jager R, Wittes R (1977) Corynebacterium parvum as adjuvant to combination chemotherapy in patients with advanced breast cancer. In: Neoplasm immunity: Solid tumor therapy. The Franklin Institute Press, Philadelphia, pp 145–151

  19. Roszkowski W, Szmigielski S, Ko HL, Janiak M, Wrembel K, Pulverer G, Jeljaszewicz J (1980) Effect of three strains of Propionibacteria (P. granulosum, P. avidum, P. acnes) and cell wall preparation on lymphocytes and macrophages. Zentralbl Bakteriol (Orig A) 246:393–404

  20. Roszkowski K, Roszkowski W, Ko HL, Szmigielski S, Pulverer G, Jeljaszewicz J (1982) Clinical experience in treatment of cancer by propionibacteria. In: Bacteria and cancer. Academic Press, London, New York, pp 331–357

  21. Szmigielski S, Roszkowski W, Roszkowskii K, Ko HL, Jeljaszewicz J, Pulverer G (1982) Experimental immunostimulation by propionibacteria. In: Bacteria and cancer. Academic Press, London, New York, pp 129–147

  22. Takita H, Moayeri H (1976) Effects of Corynebacterium parvum and chemotherapy in lung carcinoma. Proc Am Soc Clin Oncol 17:292

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Correspondence to G. Pulverer.

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Roszkowski, K., Nozdryn-Plotnicki, B., Roszkowski, W. et al. Small-cell lung cancer and immunochemotherapy withPropionibacterium granulosum KP 45. J Cancer Res Clin Oncol 109, 72–77 (1985). https://doi.org/10.1007/BF01884258

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Key words

  • Small-cell lung cancer
  • Systemic immunotherapy
  • Propionibacterium granulosum
  • Immunochemotherapy