Vitamin E in extrapyramidal disorders

  • L. Bischot
  • G. Van den Brink
  • A. J. Porsius


In this article the effect of vitamin E on two extrapyramidal disorders, tardive dyskinesia and Parkinson's disease, is reviewed. After a brief description of the symptoms, the current hypotheses for the pathogenesis of these diseases are described. A summary of the clinical research that has been done to establish the effectiveness of vitamin E is given. In tardive dyskinesia four clinical trials (double-blind, placebo-controlled) showed improvement in the symptoms with vitamin E in doses of up to 1,600 IU/day. Preliminary studies concerning Parkinson's disease suggested that vitamin E (2,000 IU/day) probably cannot prevent the development of the disease. It was suggested that vitamin E is able to slow the progression of the illness. The results from a large double-blind, placebocontrolled clinical trial, however, did not show any beneficial effect of vitamin E in Parkinson's disease.


Antioxidants Clinical trials Dyskinesia, drug-induced Free radicals Parkinson disease Pathology Vitamin E 


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Copyright information

© Periodicals Service Company 1993

Authors and Affiliations

  • L. Bischot
    • 1
  • G. Van den Brink
    • 1
  • A. J. Porsius
    • 1
  1. 1.Department of Pharmacotherapy, Faculty of PharmacyUtrecht UniversityTB UtrechtThe Netherlands

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