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Biotherapy

, Volume 8, Issue 1, pp 63–68 | Cite as

Transfer factor prevents relapses in herpes keratitis patients: A pilot study

  • Giancarlo Pizza
  • Renato Meduuri
  • Caterina De Vinci
  • Lucia Scorolli
  • Dimitri Viza
Article

Abstract

Transfer Factor is a dialysable moiety obtained from immune lymphocytes. It has been successfully used for the treatment of several viral infections including labial and genital herpes. In the present study, thirty-three patients with low immune response to HSV antigens and suffering from herpes ocular infections were orally treated with HSV-specific transfer factor (TF). Their relapse index was reduced from 20.1 before treatment to 0.51 after TF administration, with only 6/33 patients relapsing. Although this is not a placebo-controlled-randomized study, the results suggest that TF specific for HSV antigens may be efficacious for preventing relapses of ocular herpes infections as has been the case with genital and labial localisations.

Key words

Cell-mediated immunity herpes keratitis uveitis transfer factor 

Abbreviations

CMI

Cell-mediated immunity

CMV

Cytomegalo-virus

EBV

Epstein-Barr virus

HIV

Human immunodeficiency virus

HK

Herpes keratitis

HSV

Herpes simplex virus

IRI

Individual relapse index

KU

Kerato-uveitis

LMT

Leucocyte migration test

LST

Lymphocyte stimulation test

MIF

Migration inhibition factor

RHK

Relapsing herpes keratitis

TF

Transfer factor

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Giancarlo Pizza
    • 1
  • Renato Meduuri
    • 2
  • Caterina De Vinci
    • 1
  • Lucia Scorolli
    • 2
  • Dimitri Viza
    • 3
  1. 1.Immunodiagnosis and Immunotherapy Unit, 1st Division of UrologyS.Orsola-Malpighi HospitalBolognaItaly
  2. 2.Ophthalmology Clinic, S.Orsola-Malpighi Hospital, Faculty of MedicineUniversity of BolognaItaly
  3. 3.URA 1294 CNRS, Faculté de MédecineLaboratoire d 'ImmunobiologieParisFrance

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