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The lymphatic route. VIII. Distribution and plasma clearance of recombinant human interleukin-2 after SC administration with albumin in patients

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Abstract

It has been postulated that favouring the absorption of interleukin-2 via lymphatics rather than venous capillaries after subcutaneous adminstration may improve its therapeutic index. We have now evaluated in 12 cancer patients the plasma pharmacokinetic of interleukin-2 either dissolved in water or in 20% albumin solution with an internal cross-over after at least three days. Our data show that when albumin is present, the plasma concentrations of interleukin-2 versus time is increased and swelling at the injection sites is reduced. It remains to be seen whether efficacy improves during a prolonged treatment.

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Abbreviations

AUC:

Area Under Plasma Curve

BRM:

Biological Response Modifiers

IFN:

Interferon

IL-2:

Interleukin-2

IV:

Intravenous

SC:

Subcutaneous

MU:

Megaunit

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Correspondence to Velio Bocci.

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Bocci, V., Carraro, F., Zeuli, M. et al. The lymphatic route. VIII. Distribution and plasma clearance of recombinant human interleukin-2 after SC administration with albumin in patients. Biotherapy 6, 73–77 (1993). https://doi.org/10.1007/BF01877388

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Key words

  • albumin
  • interleukin 2
  • therapeutic index