, Volume 6, Issue 1, pp 13–18 | Cite as

Improvement of long-term prognosis in patients with ovarian cancers by adjuvant sizofiran immunotherapy: a prospective randomized controlled study

  • Masaki Inoue
  • Yoshiaki Tanaka
  • Nagatoshi Sugita
  • Masato Yamasaki
  • Tadashi Yamanaka
  • Junnosuke Minagawa
  • Karo Nakamuro
  • Toshiro Tani
  • Yoshio Okudaira
  • Tuguhiro Karita
  • Katsumi Takayama
  • Tatsuo Ide
  • Osamu Tanizawa
Research Articles


The effect of immunotherapy using sizofiran (SPG) on the prognosis of patients with ovarian cancers was prospectively studied in a total of 68 patients, who were randomly assigned to either a cisplatin, adriamycin and cyclophosphamide (PAC) therapy group or a PAC plus SPG combination therapy group.

The survival rate was significantly higher in patients with stage Ic, II or III cancers treated with the PAC plus SPG combination, compared with the patients treated with PAC alone. In the SPG-receiving patients with stage Ic or more advanced cancers who were treated with four cycles or more of PAC, the outcome was improved (Cox-Mantel, p=0.074; generalized Kruskal-Wallis, p=0.032). Similar improvement was also observed in the patients with non-serous adenocarcinomas (Cox-Mantel, p-0.076; generalized Krukal-Wallis, p=0.045). No side effects attributable to SPG were recorded.

The present results suggest that the use of SPG in combination with long-term chemotherapy improves the postoperative prognosis in ovarian cancer patients.

Key words

Immunotherapy Ovarian Cancer Prognosis Sizofiran 





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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Masaki Inoue
    • 1
  • Yoshiaki Tanaka
    • 2
  • Nagatoshi Sugita
    • 3
  • Masato Yamasaki
    • 4
  • Tadashi Yamanaka
    • 5
  • Junnosuke Minagawa
    • 6
  • Karo Nakamuro
    • 7
  • Toshiro Tani
    • 8
  • Yoshio Okudaira
    • 9
  • Tuguhiro Karita
    • 10
  • Katsumi Takayama
    • 11
  • Tatsuo Ide
    • 12
  • Osamu Tanizawa
    • 1
  1. 1.Department of Obstetrics and GynecologyOsaka University Medical SchoolOsakaJapan
  2. 2.Department of Obstetrics and GynecologySuita City HospitalJapan
  3. 3.Department of Obstetrics and GynecologySakai City HospitalJapan
  4. 4.Department of Obstetrics and GynecologyOsaka Rosai HospitalJapan
  5. 5.Department of Obstetrics and GynecologyItami City HospitalJapan
  6. 6.Department of Obstetrics and GynecologyMinoh City HospitalJapan
  7. 7.Department of Obstetrics and GynecologyOsaka Furitsu HospitalJapan
  8. 8.Department of Obstetrics and GynecologyKaisei HospitalJapan
  9. 9.Department of Obstetrics and GynecologyBiken HospitalJapan
  10. 10.Department of Obstetrics and GynecologyToyonaka City HospitalJapan
  11. 11.Department of Obstetrics and GynecologyKeisatsu HospitalJapan
  12. 12.Department of Obstetrics and GynecologyKaizuka City HospitalJapan

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