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Movement of thallous ion across the ascites cell membrane

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The movement of thallous ion (Tl+ across the ascites cell membrane has been characterized. Analogous to previous findings for86Rb+ (used as a tracer for K+),204Tl+-influx could be resolved into three components: a ouabain-inhibitable “pump” flux, a passive flux, and a furosemide- or NO 3 -sensitive “exchange” flux. Although Tl+ moved approximately nine times faster across the membrane than K+, the pump/leak ratio was equal for the two ions. This suggests that the pump- and leak-pathways share a common rate-limiting step. The exchange mechanism was shown to provide close coupling between the Tl+- and K+-gradients.

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  1. Bakker, E.P. 1978. Accumulation of thallous ions (Tl+) as a measure of the electrical potential difference across the cytoplasmic membrane of bacteria.Biochemistry 17:2899

  2. Bakker-Grunwald, T. 1978. Effect of anions on potassium self-exchange in ascites tumor cells.Biochim. Biophys. Acta 513:292

  3. Burckhardt, G. 1977. Non-linear relationship between fluorescence and membrane potential.Biochim. Biophys. Acta 468:227

  4. Hille, B. 1973. Potassium channels in myelinated nerve. Selective permeability to small cations.J. Gen. Physiol. 61:669

  5. Landowne, D. 1975. A comparison of radioactive thallium and potassium fluxes in the giant axon of the squid.J. Physiol. (London) 252:79

  6. Mills, B., Tupper, J.T. 1975. Cation permeability and ouabain-insensitive cation flux in the Ehrlich ascites tumor cell.J. Membrane Biol. 20:75

  7. Mills, B., Tupper, J.T. 1976. Cell cycle dependent changes in potassium transport.J. Cell. Physiol. 89:123

  8. Mitchell, P. 1968.In: Chemiosmotic Coupling and Energy Transduction. Glynn Research, Bodmin, Cornwall

  9. Sillén, L.G., Martell, A.E. 1964. Stability Constants of Metal Ion Complexes.Chem. Soc. London. Special Publication no. 17

  10. Skulskii, I.A., Manninen, V., Järnefelt, J. 1973. Interaction of thallous ions with the cation transport mechanism in erythrocytes.Biochim. Biophys. Acta 298:702

  11. Skulskii, I.A., Manninen, V., Järnefelt, J. 1978. Factors affecting the relative magnitudes of the ouabain-sensitive and the ouabain-insensitive fluxes of Tl+ in erythrocytes.Biochim. Biophys. Acta 506:233

  12. Tosteson, D.C., Hoffman, J.F. 1960. Regulation of cell volume by active cation transport in high and low potassium sheep red cells.J. Gen. Physiol. 44:169

  13. Tupper, J.T. 1975. Cation flux in the Ehrlich ascites tumor cell. Evidence for Na+-for-Na+ and K+-for-K+ exchange diffusion.Biochim. Biophys. Acta 394:586

  14. Williams, R.J.P. 1970. Biochemistry of sodium, potassium, magnesium and calcium.Chem. Soc. Q. Rev. 24:331

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Bakker-Grunwald, T. Movement of thallous ion across the ascites cell membrane. J. Membrain Biol. 47, 171–183 (1979). https://doi.org/10.1007/BF01876115

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  • Cell Membrane
  • Human Physiology
  • Furosemide
  • Exchange Mechanism
  • Close Coupling