Pharmacy World and Science

, Volume 17, Issue 3, pp 87–92 | Cite as

Stability of bupivacaine hydrochloride with diamorphine hydrochloride in an epidural infusion

  • A. R. Barnes
  • S. Nash
Practice/Case Reports


The stability of diamorphine (0.02 mg/ml as the hydrochloride) in 250 ml bupivacaine hydrochloride (0.15% wt/vol infusion) was studied by high pressure liquid chromatography at temperatures in the range 7 to 45°C. Diamorphine hydrochloride was degraded by approximately 0.13% per day at 7°C. No bupivacaine hydrochloride degradation was detectable during the study. The storage life of the combination at 7°C, based on the lower 95% confidence limit of the time to 5% diamorphine hydrochloride degradation, was 14 days. The stability at 25°C was adequate to allow transport and administration over 24 h at ambient temperature. Stability was also maintained for at least 24 h at 32 and 45°C. Infusion of the mixture with an ambulatory infusion pump which uses a standard polyvinyl chloride infusion bag is therefore possible. A study of its compatibility with different infusion pump medication reservoirs was not undertaken. The drugs were also stable on frozen storage at −18°C for up to 6 months.


Administration, epidural Bupivacaine Chromatography, high pressure liquid Diacetylmorphine Drug stability Polyvinyl chloride 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1995

Authors and Affiliations

  • A. R. Barnes
    • 1
  • S. Nash
    • 2
  1. 1.Pharmaceutical Sciences InstituteAston UniversityBirminghamUK
  2. 2.Regional Quality Control LaboratoryCity HospitalBirminghamUK

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