Neuropsychology Review

, Volume 6, Issue 2, pp 81–94 | Cite as

Gyral morphology in the posterior Sylvian region in families affected by developmental language disorder

  • Teresa Jackson
  • Elena Plante


This study describes the family aggregation of gyral morphology in the posterior perisylvian region in families that contain one or more children with a developmental language disorder. The probands in these families were 8 male and 2 female children referred through therapy programs and schools for children with language and reading problems. Family members included both biological parents (10 m, 10 f) and all available siblings (6 m, 4 f). Gyral morphology in the members of these families was compared with control subjects (10 m, 10 f) who were without a personal or family history of developmental language disorders. Gyral morphology was evaluated using T1-weighted sagittal scans from a GE Signa 1.5T magnet, 5 mm consecutive slices through the full brain volume. A less common type of Sylvian fissure morphology was more frequently found in the hemispheres of language-disordered subjects and their first-degree relatives than in control subjects. In addition, the pattern of Sylvian fissure morphology across generations within the families suggests that this feature might be inherited from either parent. The elevated rate of extra gyri in the posterior perisylvian region in families affected by language disorder links an anomaly within a language-related brain region with familial risk for this disorder.

Key Words

magnetic resonance imaging brain morphology dyslexia specific language impairment children adults 


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  1. Albanese, E., Merlo, A., Albanese, A., and Gomez, E. (1989). Anterior speech region: Asymmetry and weight-surface correlation.Archives of Neurology 46: 307–310.PubMedGoogle Scholar
  2. American National Standards Institution. (1969).Specification for Audiometers, ANSI S3.6-1969, Author, New York.Google Scholar
  3. American Psychiatric Association. (1987).Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.), Author, Washington.Google Scholar
  4. Benton, A., and deS Hamsher, K. (1978).Multilingual Aphasia Examination, AJA Associates, Iowa City, IA.Google Scholar
  5. Brown, L., Sherbenou, R. J., and Johnsen, S. K. (1990).Test of Nonverbal Intelligence-2 Pro-Ed, Austin, TX.Google Scholar
  6. Chi, J. G., Dooling, E. C., and Gilles, F. H. (1977a). Left-right asymmetries of the temporal speech areas of the human fetus.Archives of Neurology 34: 346–348.PubMedGoogle Scholar
  7. Chi, J., Dooling, E. C., and Gilles, F. H. (1977b). Gyral development of the human brain.Annals of Neurology 1: 86–93.PubMedGoogle Scholar
  8. Cohen, M., Campbell R., and Yaghmai F. (1989). Neuropathological abnormalities in developmental dysphasia.Annals of Neurology 25: 567–570.PubMedGoogle Scholar
  9. Dunn, L. M., and Dunn, L. M. (1981).Peabody Picture Vocabulary Test—Revised, American Guidance Service, Circle Pines MN.Google Scholar
  10. Falzi, G., Perrone, P., Luigi, A., and Vignolo, L. (1982). Right-left asymmetry in anterior speech region.Archives of Neurology 39: 239–240.PubMedGoogle Scholar
  11. Galaburda, A. M., Sherman, G. F., Rosen, G. D., Aboitiz, F., and Geschwind, N. (1985). Developmental dyslexia; Four consecutive patients with cortical anomalies.Annals of Neurology 18: 222–233.PubMedGoogle Scholar
  12. Geschwind, N., and Levitsky, W. (1968). Human brain: Asymmetries in the temporal speech region.Science 161: 186–187.PubMedGoogle Scholar
  13. Humphreys, P., Kaufmann, W. E., and Galaburda, A. M. (1990). Developmental dyslexia in women: Neuropathological findings in three patients.Annals of Neurology 28: 727–738.PubMedGoogle Scholar
  14. Hynd, G. W., Semrud-Clikeman, M., Lorys, A. R., Novey, E. S., and Eliopulos, D. (1990). Brain morphology in developmental dyslexia and attention deficit disorder/hyperactivity.Archives of Neurology 47: 919–926.PubMedGoogle Scholar
  15. Jernigan, T. L., Hesselink, J. R., Sowell, E., and Tallal, P. A. (1991). Cerebral structure on magnetic resonance imaging in language- and learning-impaired children.Archives of Neurology 48: 539–545.PubMedGoogle Scholar
  16. Kaufman, A. S., and Kaufman, N. L. (1983).Kaufman Assessment Battery for Children, American Guidance Service, Circle Pines, MN.Google Scholar
  17. Leonard, C. M., Voeller, K. S., Lombardino, L. J., Morris, M. K., Hynd, G. W., Alexander, A. W., Anderson, H. G., Garofalakis, M., Honeyman, J. C., Mao, J., Agee, O. F., and Staab, E. V. (1993). Anomalous cerebral structure in dyslexia revealed with magnetic resonance imaging.Archives of Neurology 50: 461–469.PubMedGoogle Scholar
  18. Morice, R., and McNicol, D. (1985). The comprehension and production of complex syntax in schizophrenia.Cortex 21: 567–580.PubMedGoogle Scholar
  19. Neils, J., and Aram, D. M. (1986). Family history of children with developmental language disorders.Perceptual and Motor Skills 63: 655–658.PubMedGoogle Scholar
  20. Plante, E. (1991). MRI findings in the parents and siblings of specifically language-impaired boys.Brain and Language 40: 67–80.PubMedGoogle Scholar
  21. Plante, E., Swisher, L., Vance, R., and Rapcsak, S. (1991). MRI findings in boys with specific language impairment.Brain and Language 40: 52–66.Google Scholar
  22. Plante E., and Vance, R. (1994). Selection of preschool language tests: A data-based approach.Language, Speech, and Hearing Services in Schools 25: 15–24.Google Scholar
  23. Plante E., and Vance, R. (1995). Diagnostic accuracy of two tests of preschool language skills.American Journal of Speech-Language Pathology 4: 70–76.Google Scholar
  24. Rubens, A. B., Mahowald, M. W., and Hutton, J. T. (1976). Asymmetry of the lateral (Sylvian) fissures in man.Neurology 26: 620–624.PubMedGoogle Scholar
  25. Semel, E., Wiig, E. H., and Secord, W. (1987).Clinical Evaluation of Language Fundamentals—Revised, Psychological Corporation, San Antonio, TX.Google Scholar
  26. Steinmetz, H., Eberling, U., Huang, Y., and Kahn, T. (1990). Sulcal topography of the parietal opercular region: an anatomic and MR study.Brain and Language 38: 515–533.PubMedGoogle Scholar
  27. Tallal, P., Ross, R., and Curtiss, S. (1989). Familial aggregation in specific language impairment.Journal of Speech Hearing Disorders 54: 167–173.Google Scholar
  28. Tomblin, J. B. (1989). Familial concentrations of developmental language impairment.Journal of Speech Hearing Disorders 54: 287–295.Google Scholar
  29. Tomblin, J. B., Freese, P. R., and Records, N. L. (1992). Diagnosing specific language impairment in adults for the purpose of pedigree analysis.Journal of Speech and Hearing Research 35: 832–843.PubMedGoogle Scholar
  30. Wada, J. A., Clarke, R., and Hamm, A. (1975). Cerebral hemispheric asymmetry in humans.Archives of Neurology 32: 239–246.PubMedGoogle Scholar
  31. Werner, E. and Kresheck, J. D. (1983).Structured Photographic Expressive Language Test—II, Janelle Publications, Sandwich, IL.Google Scholar
  32. Witelson, S. F., and Pallie, W. (1973). Left hemisphere specialization for language in the newborn.Brain 96: 641–646.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Teresa Jackson
    • 1
  • Elena Plante
    • 2
  1. 1.Department of BiochemistryThe University of ArizonaTucson
  2. 2.The Department of Speech and Hearing SciencesThe University of ArizonaTucson

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