Pharmacy World and Science

, Volume 16, Issue 5, pp 231–232 | Cite as

Possible potentiation of anticoagulant effect of acenocoumarol by omeprazole

  • Benito García
  • Carmen Lacambra
  • Francisco Garrote
  • Isabel García-Plaza
  • Javier Solis
Letters to the Editor


Acenocoumarol Cytochrome P-450 Drug synergism Omeprazole Thrombosis 


  1. 1.
    Henry DA, Somerville KW, Kitchingman G, Langman MJS. Omeprazole: effects on oxidative drug metabolism. Br J Clin Pharmacol 1984;18:195–200.Google Scholar
  2. 2.
    Andersson T. Omeprazole drug interaction studies. Clin Pharmacokinet 1991;21:195–212.Google Scholar
  3. 3.
    Andersson T. Lagerstrom PO, Unge P. A study of the interaction between omeprazole and phenytoin in epileptic patients. Ther Drug Monit 1990;12:329–33.Google Scholar
  4. 4.
    Gugler R, Jensen JC. Omeprazole inhibits elimination of diazepam [letter]. Lancet 1984;1:969.Google Scholar
  5. 5.
    Geneve J, Bocquentin M, Taburet AM, Simoneau G, Caulin C, Singlas E. Effects of omeprazole on theophylline metabolism in healthy subjects [abstract]. Gastroenterology 1991;100:A69.Google Scholar
  6. 6.
    Henry D, Brent P, Whyte I, Mihaly G, Devenish-Meares S. Propranolol steady-state pharmacokinetics are unaltered by omeprazole. Eur J Clin Pharmacol 1987;33:369–73.Google Scholar
  7. 7.
    Blohme I, Andersson T, Idstrom JP. No interaction between omeprazole and cyclosporine [abstract]. Gastroenterology 1991;100:A721.Google Scholar
  8. 8.
    Sutfin T, Balmer K, Bostrom H, Eriksson S, Hoglund P, Paulsen O. Stereoselective interaction of omeprazole with warfarin in healthy men. Ther Drug Monit 1989;11:176–84.Google Scholar
  9. 9.
    Unge P, Sverberg LE, Nordgren A, Blom H, Andersson T, Lagerstrom PO, et al.. A study of the interaction of omeprazole and warfarin in anticoagulated patients. Br J Clin Pharmacol 1992;34:509–12.Google Scholar
  10. 10.
    Ahmad S. Omeprazole-warfarin interaction [letter]. South Med J 1991;84:674–5.Google Scholar
  11. 11.
    Meinertz T, Kasper W, Kahl C, Jahnchen E. Anticoagulant activity of the enantiomers of acenocoumarol. Br J Clin Pharmacol 1978;5:187–8.Google Scholar
  12. 12.
    Choonara I, Cholerton S, Haynes BP, Breckenridge AM, Park BK. Stereoselective interaction between theR-enantiomer of warfarin and cimetidine. Br J Clin Pharmacol 1986;21:271–7.Google Scholar
  13. 13.
    Gill TS, Hopkins KJ, Bottomley J, Gupta SK, Rowland M. Cimetidine-nicoumalone interaction in man: stereochemical considerations. Br J Clin Pharmacol 1989;27:469–74.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1994

Authors and Affiliations

  • Benito García
    • 1
  • Carmen Lacambra
    • 2
  • Francisco Garrote
    • 2
  • Isabel García-Plaza
    • 3
  • Javier Solis
    • 2
  1. 1.Pharmacy ServiceHospilal La PazMadridSpain
  2. 2.Internal Medicine ServiceHospital Severo OchoaLeganesSpain
  3. 3.Haematology ServiceHospital Severo OchoaSpain

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