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Pharmacy World and Science

, Volume 15, Issue 6, pp 269–275 | Cite as

Effect of glucose 5% solution and bupivacaine hydrochloride on absorption of sufentanil citrate in a portable pump reservoir during storage and simulated infusion by an epidural catheter

  • P. J. Roos
  • J. H. Glerum
  • M. J. H. Schroeders
Practicle/Case Reports

Abstract

The stability of sufentanil (5 μg/ml as citrate) in admixtures with glucose 5% or bupivacaine hydrochloride (2 mg/ml) in 100 ml polyvinyl chloride portable pump reservoirs was investigated during simulated infusion by an epidural catheter at 32°C for 48 h and during storage at 4°C and 32°C for 30 days. During both experiments a small decrease (<5%) in concentration of sufentanil and bupivacaine was observed. No loss of sufentanil or bupivacaine could be detected (in both experiments) in the portable pump reservoirs when stored at 4°C for 30 days. A significant decrease of sufentanil was observed when stored at 32°C after 30 days when diluted with glucose (9.2%) or in combination with bupivacaine (8.9%); also, the bupivacaine concentration decreased significantly (4.7%). It is concluded that sufentanil in portable pump reservoirs can be used under patient conditions at 32°C for 7 days when diluted with glucose 5% or 3 days in combination with bupivacaine hydrochloride.

Keywords

Absorption Bupivacaine Compatibility Drug stability Drug therapy, combination Epidural administration Glucose Polyvinyl chloride Sufentanil 

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References

  1. 1.
    Beijnen JH. Home-based chemotherapy confronts pharmacists with stability and compatibility problems. Pharm Weekbl Sci 1992;14(6):337.Google Scholar
  2. 2.
    Tu Y, Stiles ML, Allen LV. Stability of fentanyl citrate and bupivacaine hydrochloride in portable pump reservoirs. Am J Hosp Pharm 1990;47:2037–40.Google Scholar
  3. 3.
    Dawson PJ, Bjorksten AR, Duncan IP, Barnes RK, Beemer GH. Stability of fentanyl, bupivacaine and adrenaline solutions for extradural infusion. Br J Anaesth 1992;68:414–7.Google Scholar
  4. 4.
    Boersma FP, Brouwers JRBJ, Van Doorne H, Meevis RF. Stability of sufentanil citrate and sufentanil citrate/bupivacaine mixture in portable infusion pump reservoirs. In: Boersma FP. Epidural cancer pain control on a outpatient basis [dissertation]. Amsterdam: Vrije Universiteit, 1993:95–100.Google Scholar
  5. 5.
    Roos PJ, Glerum JH, Meilink JW. Stability of sufentanil citrate in a portable pump reservoir, a glass container and a poly-ethylene container. Pharm Weekbl Sci 1992;14(4):196–200.Google Scholar
  6. 6.
    Roos PJ, Glerum JH, Meilink JW, Zwang L. Effect of pH on absorption of sufentanil citrate in a portable pump reservoir during storage and administration under simulated epidural conditions. Pharm World Sci 1993;15(3):139–44.Google Scholar
  7. 7.
    Hogan Q, Haddox JD, Abram S, Weissman D, Taylor ML, Janjan N. Epidural opiates and local anesthetics for the management of cancer pain. Pain 1991;46:271–9.Google Scholar
  8. 8.
    Boersma FP, Noorduin H, Vanden Bussche G. Epidural sufentanil for cancer pain control patients. In: Boersma FP. Epidural cancer pain control on an outpatient basis [dissertation]. Amsterdam: Vrije Universiteit, 1993:25–32.Google Scholar
  9. 9.
    Ziegenmeyer J. Biopharmazeutische Aspekte bei der Anwendung von Dermatika. In: Niedner R. Dermatika. Stuttgart: Wissenschaftliche Verlagsgesellschaft, 1992:300–1.Google Scholar
  10. 10.
    Netherlands Pharmacopoeia. 9th ed. 's-Gravenhage: Staatsuitgeverij, 1983.Google Scholar
  11. 11.
    Allen LV, Stiles ML, Wang DP, Tu YH. Stability of bupivacaine hydrochloride, epinephrine hydrochloride, and fentanyl citrate in portable infusion-pump reservoirs. Am J Hosp Pharm 1993;50:714–5.Google Scholar
  12. 12.
    Lohman JJHM, Lanssen MJ, Cilissen J, Hendriks MWG, Hooymans PM, Janknegt R. Compatibility of morphine hy-drochloride and bupivacaine hydrochloride in a portable pump reservoir [abstract]. Pharm Weekbl Sci 1992;14 (Suppl. F):F27.Google Scholar
  13. 13.
    Roos PJ, Glerum JH, Meilink JW. Stability of morphine hydrochloride in a portable pump reservoir. Pharm Weekbl Sci 1992;14(1):23–6.Google Scholar
  14. 14.
    Roos PJ. Absorptie van sufentanil [Absorption of sufentanil]. Pharm Weekbl 1992;127(40):1066.Google Scholar

Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1993

Authors and Affiliations

  • P. J. Roos
    • 1
  • J. H. Glerum
    • 2
    • 3
  • M. J. H. Schroeders
    • 1
  1. 1.Department of PharmacyAcademic Medical CentreAZ AmsterdamThe Netherlands
  2. 2.Department of PharmacyUniversity Hospital UtrechtCX UtrechtThe Netherlands
  3. 3.Department of Pharmaceutics, Faculty of PharmacyUtrecht UniversityCA UtrechtThe Netherlands

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