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Pharmacy World and Science

, Volume 16, Issue 1, pp 18–21 | Cite as

The preservation of some oral liquid preparations

The replacement of chloroform by other preservatives
  • H. van Doorne
  • J. B. Leijen
Practice/Case Reports

Abstract

Chloroform should be considered as an obsolete preservative for pharmaceutical preparations, because of its toxicological implications and its physical instability. The effectiveness of possible alternatives for chloroform in three oral liquid pharmaceutical preparations was investigated, using a microbiological challenge test. Magnesium trisilicate mixture (British Pharmacopoeia) can be adequately preserved with methylparaben (2 g/l). Only insignificant amounts of methylparaben were absorbed by the solids present in the magnesium trisilicate mixture. Ferrous sulfate mixture (British Pharmacopoeia) can be preserved with a mixture of methylparaben (1.8 g/l) and propylparaben (0.2 g/l). Sorbic acid (1 g/l) is a suitable preservative for promethazine hydrochloride syrup.

Keywords

Chloroform Drug stability Ferrous sulfate Magnesium trisilicate Parabens Promethazine Sorbic acid 

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References

  1. 1.
    Reynolds JEF, editor. Martindale, the extra pharmacopoeia. 28th edition. London: The Pharmaceutical Press, 1982:745–6.Google Scholar
  2. 2.
    British Pharmacopoeia. London: Her Majesty's Stationery Office, 1988.Google Scholar
  3. 3.
    United States Pharmacopeia XXII. Rockville: United States Pharmacopeial Convention, 1990:1478–9.Google Scholar
  4. 4.
    Vanhaecke E, Remon JP, Pijck J, Aerts R, Herman J. A comparative study of the effectiveness of preservatives in twelve antacid suspensions. Drug Dev Ind Pharm 1987;13:1429–46.Google Scholar
  5. 5.
    Van Doorne H. Interactions between preservatives and pharmaceutical components. In: Denyer S, Baird R, editors. Guide to microbiological control in pharmaceuticals. Chichester: Ellis Horwood, 1990:274–91.Google Scholar
  6. 6.
    Tromp ThFJ. Various aspects of the microbiological quality of pharmaceutical preparations [dissertation]. Groningen: University of Groningen, 1983.Google Scholar
  7. 7.
    Van Doorne H, Wieringa NF, Bosch EH, De Meijer R. The suitability of some preservatives in chloroquine phosphate syrup. Pharm Weekbl Sci 1988; 10:170–2.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1994

Authors and Affiliations

  • H. van Doorne
    • 1
  • J. B. Leijen
    • 1
  1. 1.Department of Pharmaceutical Technology and BiopharmacyUniversity of GroningenAV Groningenthe Netherlands

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