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Pharmacy World and Science

, Volume 17, Issue 6, pp 222–224 | Cite as

Bioanalysis and clinical pharmacokinetics of antiretroviral agents in HIV-infected individuals

  • David M. Burger
Doctoral Theses
  • 21 Downloads

Conclusions

The research described in this thesis has given us more insight into the various aspects of the clinical pharmacokinetic behaviour of antiretroviral agents in HIV-infected individuals. Especially our knowledge of the pharmacokinetics of zidovudine has been enhanced, but data for didanosine and zalcitabine are still scarce. In all situations, the pharmacokinetics in subgroups of patients may be altered, also as a result of drug interactions. The next years special attention should be paid to pharmacokinetic-pharmaco-dynamic relationships. The above described research has created a basis for this kind of investigation.

Keywords

Acquired immunodeficiency syndrome Chemistry, analytical Didanosine Drug interactions HIV Pharmacokinetics Zalcitabine Zidovudine 

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Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1995

Authors and Affiliations

  • David M. Burger
    • 1
    • 2
  1. 1.Utrecht Universitythe Netherlands
  2. 2.Department of PharmacySlotervaart HospitalEC Amsterdamthe Netherlands

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