Pharmacy World and Science

, Volume 17, Issue 6, pp 214–217 | Cite as

Preparation and stability testing of a hydrogel for topical analgesia

  • Y. L. M. Nortier
  • J. A. van de Haven
  • C. H. W. Koks
  • J. H. Beijnen
Practice/Case Reports


With the commercial availability of a cream (EMLA®) containing a eutectic mixture of local anaesthetics, 2.5% (w/w) lidocaine and 2.5% (w/w) prilocaine, effective topical anaesthesia of the intact skin is possible without the need for subcutaneous injections or exposure to high concentrations of local anaesthetics. In our hospital a topical anaesthetic product was designed for the same purpose. The home-made product contains a eutectic mixture of a local anaesthetic (5% w/w) and l-menthol (1% w/w). Prilocaine was used as the local anaesthetic because it is known for its safety and its well investigated analgesic effects. The eutectic mixture of prilocaine and l-menthol was mixed with a carbopol hydrogel (1% w/w). Preliminary testing of this anaesthetic hydrogel in our hospital has yielded satisfactory results. The anaesthetic hydrogel was found to be stable after at least 3 months' storage at ambient temperature.


Anesthetics, local Chemistry, analytical Drug compounding Drug stability Eutectic mixture Hydrogels Menthol Prilocaine 


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Copyright information

© Royal Dutch Association for the Advancement of Pharmacy 1995

Authors and Affiliations

  • Y. L. M. Nortier
    • 1
  • J. A. van de Haven
    • 2
  • C. H. W. Koks
    • 1
  • J. H. Beijnen
    • 1
  1. 1.Department of PharmacySlotervaart HospitalEC, Amsterdamthe Netherlands
  2. 2.Department of AnaesthesiologySlotervaart HospitalAmsterdamthe Netherlands

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