The Journal of Membrane Biology

, Volume 17, Issue 1, pp 101–120 | Cite as

Thermodynamic constants for nonelectrolyte partition between dimyristoyl lecithin and water

  • Yehuda Katz
  • Jared M. Diamond


Partition coefficients (K's) between dimyristoyl lecithin liposomes and water were measured as a function of temperature for 16 nonelectrolytes. FromK and its temperature dependence, the partial molar free energy (ΔF), enthalpy (ΔH) and entropy (ΔS) of partition for each solute were extracted. By subtraction of ΔF, ΔH and ΔS of hydration of each solute (where known), ΔF, ΔH and ΔS of solution in lecithin could be calculated for some solutes. Among different solutes ΔS of solution increases approximately linearly with ΔH of solution, as also found in bulk solvents (the so-called Barclay-Butler relations). The Barclay-Butler slopedΔS/dΔH is approximately twice as steep for lecithin as for bulk nonpolar solvents. This effect is attributed in part to greater immobilization of solutes in bilayers than in bulk solvents.


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Copyright information

© Springer-Verlag New York Inc. 1974

Authors and Affiliations

  • Yehuda Katz
    • 1
  • Jared M. Diamond
    • 1
  1. 1.Department of PhysiologyUniversity of California Medical CenterLos Angeles

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