Cardiovascular Drugs and Therapy

, Volume 4, Issue 2, pp 529–530 | Cite as

Stability of plasma amiodarone levels during chronic oral therapy

  • Killian Robinson
  • Atholl Johnston
  • Simon Walker
  • John Mulrow
  • David Holt
  • William McKenna
Arrhythmias

Summary

The variability of plasma amiodarone levels in 51 patients receiving chronic oral therapy over 4–53 (median 19) months was examined; 3–14 (median 5) plasma samples were obtained. After a loading dose, most patients received either 200mg or 400mg a day. Mean plasma amiodarone concentration was 1.2±0.6mg/l and mean plasma desethylamiodarone concentration, was 1.2±0.5mg/l. No relationship was seen between height and weight and plasma concentrations. Dose was a significant predictor of plasma level (p<0.01) although it was a poor predictor of steady state amiodarone concentration.

Key Words

amiodarone pharmacokinetics arrhythmias 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Killian Robinson
    • 1
  • Atholl Johnston
    • 3
  • Simon Walker
    • 2
  • John Mulrow
    • 1
  • David Holt
    • 2
  • William McKenna
    • 1
  1. 1.Cardiological SciencesSt. Georges Hospital Medical SchoolLondonEngland
  2. 2.Poisons UnitGuy's HospitalLondonEngland
  3. 3.Department of Clinical PharmacologySt. Bartholomew's HospitalLondonEngland

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