Stability of plasma amiodarone levels during chronic oral therapy
The variability of plasma amiodarone levels in 51 patients receiving chronic oral therapy over 4–53 (median 19) months was examined; 3–14 (median 5) plasma samples were obtained. After a loading dose, most patients received either 200mg or 400mg a day. Mean plasma amiodarone concentration was 1.2±0.6mg/l and mean plasma desethylamiodarone concentration, was 1.2±0.5mg/l. No relationship was seen between height and weight and plasma concentrations. Dose was a significant predictor of plasma level (p<0.01) although it was a poor predictor of steady state amiodarone concentration.
Key Wordsamiodarone pharmacokinetics arrhythmias
- 3.Staubli M, Bircher J, Caleazzi RL, et al. Serum concentrations of amiodarone during long term therapy: Relation to dose efficacy and toxicity.Eur J Clin Pharm 1983;24:485–494.Google Scholar
- 5.Andreasen F, Agerback H, Bjerregard P, et al. Pharmacokinetics of amiodarone after intravenous and oral administration.Eur J Clin Pharm 1981;19.:2–9.Google Scholar