Cardiovascular Drugs and Therapy

, Volume 4, Issue 3, pp 751–754 | Cite as

The effect of captopril on peripheral hemodynamics in patients with esential hypertension: Comparison between oral and sublingual administration

  • Carlo Longhini
  • Lucia Ansani
  • GianFranca Musacci
  • Donato Mele
  • Marco Vaccari
  • Enrico Baracca
  • Paolo Sgobino


A comparative study of the effects of oral and sublingual captopril on the hemodynamics of the peripheral musculocutaneous vasculature was carried out on ten patients with essential hypertension. Both routes of administration of captopril lead to lower blood pressure and decreased regional resistance, and to an increased arterial blood flow at rest. The first measurable effect and the peak effect on blood pressure and peripheral hemodynamics appear slightly earlier with sublingual administration. The data provided in this study support the usefulness of the sublingual route in clinical situations in which oral administration of captopril is not feasible.

Key Words

captopril peripheral hemodynamics essential hypertension strain gauge plethysmography sublingual administration 


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Carlo Longhini
    • 1
  • Lucia Ansani
    • 1
  • GianFranca Musacci
    • 1
  • Donato Mele
    • 1
  • Marco Vaccari
    • 1
  • Enrico Baracca
    • 1
  • Paolo Sgobino
    • 1
  1. 1.Istituto di Clinica MedicaUniversita' di FerraraFerraraItaly

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