2-Chloroethylstearate: An in vivo fatty acid conjugate of 2-chloroethanol

  • B. S. Kaphalia
  • G. A. S. Ansari


Waste Water Water Management Water Pollution Acid Conjugate Fatty Acid Conjugate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Andrews JE, Courtney KD, Donaldson WE (1983) The effect of ethylene chlorohydrin on fatty acid synthesis. J Environ Sci Hlth 1318:351–367Google Scholar
  2. Ansari GAS, Britt SG, Reynolds ES (1985) Isolation and characterization of palmitoylpentachlorophenol fron human fat. Bull Environ Contam Toxicol 34:661–667PubMedGoogle Scholar
  3. Ansari GAS, Kaphalia BS, Boor PJ (1987) Selective pancreatic toxicity of palmitoylpentachlorophenol (Submitted)Google Scholar
  4. Bruns GW, Currie RA (1983) Determination of 2-chloroethanol in honey, beeswax, and pollen. J Assoc Off Anal Chem 66:659–662PubMedGoogle Scholar
  5. DeRudder D, DeGraeve E, Van Severen R, Braeckman P (1986) Quantitation of ethylene chlorohydrin and ethylene glycol as the potential reaction products of gas-sterilized medical grade plastics. J Clin Hosp Pharm 11:125–130PubMedGoogle Scholar
  6. Folch J, Lees M, Stanley, GHS (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509PubMedGoogle Scholar
  7. Godeneche D, Moreau MF, Madelmont JC, Duprat J, Plagne R (1982) Disposition and metabolism of 1-(2-chloroethyl)-3-(2′,3′,4′-tri-o-acetyl ribopyranosyl)-1-nitrosourea in rats. Cancer Res 42:525–529PubMedGoogle Scholar
  8. Grunow W, Altmann HJ (1982) Toxicokinetics of chloroethanol in the rat after single oral administration. Arch Toxicol 49:275–284PubMedGoogle Scholar
  9. Guengerich FP, Crawford WM, Domoradzki JY, MacDonald TL, Watanabe PG (1980)In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. Toxicol Appl Pharmacol 55:303–317PubMedGoogle Scholar
  10. Heikes DL, Griffitt KR (1979) Identification of 2-chloroethyl palmitate and 2-chloroethyl linoleate in French dressing. Bull Environ Contam Toxicol 21:98–101PubMedGoogle Scholar
  11. Leighty EG, Fentiman Jr AF, Foltz RL (1976) Long retained metabolites of Δ9- and Δ8-tetrahydrocannabinols identified as novel fatty acid conjugates. Res Commun Chem Pathol Pharmacol 14:13–28PubMedGoogle Scholar
  12. Leighty EG, Fentiman Jr AF, Thompson RM (1980) Conjugation of fatty acids to DDT in the rat: Possible mechanism of retention. Toxicology 15:77–82PubMedGoogle Scholar
  13. Madelmont JC, Moreau MF, Godenech D, Duprat J, Plagne R, Meyniel G (1982) Main metabolites of 1-(2-chloroethyl)-3-[1′-(5′-p-nitrobenzoyl-2′, 3′-isopropylidine)-α,β-D-Ribofuranosyl]-1-nitrosourea and 1-(2-chloroethyl)-3-(2′,3′, 4′-tri-o-acetyl-α,β-D-ribopyranosyl)-1-nitrosourea in rats. Drug Metab Dispos 10:662–666PubMedGoogle Scholar
  14. McCall SN, Jurgens P, Ivanetich KM (1983) Hepatic microsomal metabolism of the dichloroethanes. Biochem Pharmacol 32:207–213PubMedGoogle Scholar
  15. Merckx J, Kinget R (1986) Ethylene chlorohydrin determination in ethylene oxide sterilized polyvinyl chloride tubing. J Clin Hosp Pharm 11:357–363PubMedGoogle Scholar
  16. Muzeni RJ (1985) Rapid gas chromatographic determination of ethylene oxide, ethylene chlorohydrin, and ethylene glycol residues in rubber catheters. J Assoc Off Anal Chem 68:506–508PubMedGoogle Scholar
  17. Norpoth K, Heger M, Muller G, Mohtashamipur E, Kemena A, Witting C (1986) Investigations on metabolism, genotoxic effects and carcinogenicity of 2,2′-dichloroethylene ether. J Cancer Res Clin Oncol 112:125–130PubMedGoogle Scholar
  18. Pfeilsticker K, Leyendecker A (1978) Restmengen von ethylenchlorhydrin (ECH) in kakaotrunk und Schokolade. Z Lebensm Unters Forsch 167:329–332PubMedGoogle Scholar
  19. Reed DJ, May HE, Boose RB, Gregory KM, Beilstein MA (1975) 2-Chloroethanol formation as evidence for 2-chloroethyl alkylating intermediate during chemical degradation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea and 1-(2-chloroethyl)-3-(trans-4-nethylcyclohexyl)-1-nitrosourea. Cancer Res 35:568–576PubMedGoogle Scholar
  20. Remmer H, Greim H, Schenkman JB, Estabrook, RW (1967) Methods for the elevation of hepatic microsomal mixed functional oxidase levels and cytochrome P-450. Methods in Enzymology 10:703–710Google Scholar
  21. Stijve T, Kalsbach R, Eyring G (1976) Determination and occurrence of ethylene chlorohydrin residues in food stuffs fumigated with ethylene oxide. Trav Chim Aliment Hyg 67:403–428Google Scholar
  22. Yllner S (1971) Metabolism of 1,2-dichloroethane-14C in the mouse. Acta Pharmacol Toxicol 30:257–265Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • B. S. Kaphalia
    • 1
  • G. A. S. Ansari
    • 1
  1. 1.Chemical Pathology Division, Department of PathologyThe University of Texas Medical BranchGalveston

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