Research in Experimental Medicine

, Volume 187, Issue 6, pp 423–427 | Cite as

Influence of dextran on pneumococcal septicemia in splenic artery-ligated or splenectomized rats

  • R. Andersson
  • A. Alwmark
  • S. Bengmark
Original Papers


Splenic artery ligation is one of several methods in splenic preservation. In this experimental work the susceptibility of splenectomized rats and rats treated with splenic artery ligation to pneumococcal infection and the influence of the plasma expander dextran in the same groups were studied. The mortality among splenectomized rats was 100% vs nil after sham operation. Animals treated with splenic artery ligation and saline had a 23% mortality in pneumococcal septicemia, significantly different (P<0.05) from the 59% mortality after splenic artery ligation and dextran. A significant increase (P < 0.05) in number of abscesses was also seen among rats given dextran.

Key words

Splenic artery Ligation Pneumococcal infection Dextran Rats 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alwmark A, Bengmark S,Gullstrand P, Schalén C (1981) Improvement of the splenectomized rat model for overwhelming pneumococcal infection. Eur Surg Res 13:339–343PubMedGoogle Scholar
  2. 2.
    Andersson R, Alwmark A, Bengmark S (1986) Outcome of pneumococcal challenge in rats after splenic artery ligation or splenectomy. Acta Chir Scand 152:15–17PubMedGoogle Scholar
  3. 3.
    Andersson R, Gustavsson T, Alwmark A (1985) Splenic artery ligation for traumatic rupture of the spleen. Acta Chir Scand 151:709–710PubMedGoogle Scholar
  4. 4.
    Bradfield JWB, Souhami RL, Addison IE (1974) The mechanism of the adjuvant effect of dextran sulphate. Immunology 26:383–392PubMedGoogle Scholar
  5. 5.
    Douglas GJ, Simpson JS (1971) The conservative management of splenic trauma. J Pediatr Surg 6:565–570PubMedGoogle Scholar
  6. 6.
    Høivik B, Solheim K (1983) Splenic artery ligation in splenic injuries. Injury 15:1–5PubMedGoogle Scholar
  7. 7.
    Keramidas DC (1979) The ligation of the splenic artery in treatment of traumatic rupture of the spleen. Surgery 85:530–533PubMedGoogle Scholar
  8. 8.
    Keramidas DC, Voyatzis N, Anagnostou D, Stavrides J, Koutoulides C, Ziros A (1980) Ligation of the splenic artery: Effect on the injured spleen and its function. J Pediatr Surg 15:38–41PubMedGoogle Scholar
  9. 9.
    King H, Shumacker H Jr (1952) Splenic studies. Ann Surg 136:239–242PubMedGoogle Scholar
  10. 10.
    Lahnborg G, Berghem L, Jarstrand C (1979) Effects of dextran infusion on the phagocytic and metabolic functions of the reticuloendothelial system in man. Acta Chir Scand [Suppl] 489:271–277Google Scholar
  11. 11.
    Leonard AS, Giebink GS, Baesl TJ, Krivit W (1980) The overwhelming postsplenectomy sepsis problem. World J Surg 4:423–432PubMedGoogle Scholar
  12. 12.
    Leung LE, Szal GJ, Drachman RH (1972) Increased susceptibility of splenectomized rats to infection with Diplococcus pneumoniae. J Infect Dis 507–513Google Scholar
  13. 13.
    Morrison JL, Bloom WL, Richardson AP (1951) Effect of dextran on the rat. J Pharmacol Exp Ther 101:27–28Google Scholar
  14. 14.
    Morrison JL, Richardson AP, Bloom WL (1951) The effects of antihistaminic agents on the reaction of the rat to dextran. Arch Intern Pharmacodyn 88:98–105Google Scholar
  15. 15.
    Pabst R, Kamran D, Creutzig G (1978) Splenic regeneration and blood flow after ligation of the splenic artery or partial splenectomy. Am J Surg 147:382–386Google Scholar
  16. 16.
    Schildt B, Bouveng R, Sollenberg M (1975) Plasma substitute induced impairment of the reticuloendothelial system function. Acta Chir Scand 141:7–13PubMedGoogle Scholar
  17. 17.
    Sekikawa T, Shatney CH (1983) Septic sequelae after splenectomy for trauma in adults. Am J Surg 145:667–673PubMedGoogle Scholar
  18. 18.
    Sherman NJ, Asch MJ (1978) Conservative surgery for splenic injuries. Pediatric 61:267–271Google Scholar
  19. 19.
    Tam PE, Hinsdill RD (1984) Evaluation of immunomodulatory chemicals: Alteration of macrophage function in vitro. Toxicol Appl Pharmacol 76:183–194PubMedGoogle Scholar
  20. 20.
    Witte CL, Witte MH, Renart W, O'Mara RE, Lilion DL (1976) Splenic artery ligation in selected patients with hepatic cirrhosis and in Sprague-Dawley rats. Surg Gynecol Obstet 142:1–12PubMedGoogle Scholar
  21. 21.
    Voorhees AB, Baker HJ, Pulaski EJ (1951) Reactions of albino rats to injection of dex tran. Proc Soc Exp Biol Med 76:254–256PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • R. Andersson
    • 1
  • A. Alwmark
    • 1
  • S. Bengmark
    • 1
  1. 1.Dept. of SurgeryLund UniversityLundSweden

Personalised recommendations